摘要
目的:观察补肾活血汤对急性脑梗死患者的神经功能及血清SOD水平的影响。方法:将60例肾虚血瘀型急性脑梗死患者随机分为治疗组与对照组,每组30例。所有患者均给予西医常规治疗,治疗组在此基础上给予补肾活血汤治疗,治疗周期为2周。采用美国国立卫生研究院卒中量表(NIHSS)评定患者的神经功能缺损程度,比较两组患者治疗前后的血清超氧化物歧化酶(SOD)水平及临床疗效。结果:治疗后,治疗组的总有效率为90.0%,对照组为73.3%,治疗组的疗效优于对照组(P<0.05);两组患者的NIHSS评分较治疗前均显著降低(P<0.05),且治疗组患者的评分低于对照组(P<0.05);治疗组患者的血清SOD水平较治疗前显著升高(P<0.05),且显著高于对照组(P<0.05)。结论:补肾活血汤能够降低急性脑梗死患者的血清SOD水平,从而起到保护神经细胞的作用。
Objective ： To observe the effect of “Bushen Huoxue Decoction” on the nerve function and the level of serum super oxide dismutase （SOD） in patients with acute cerebral infarction. Methods： Sixty patients with acute cerebral infarction of kidney deficiency, and blood stasis type were randomly divided into treatment group and control group, with 30 cases in each group. All the patients were treated with conventional western medicine, and the patients in the treatment group were treated with “Bushen Huoxue Decoction” in addition, with the course of 2 weeks. The nerve function was evaluated by National Institute of Health stroke scale （NIHSS）, the level of serum SOD was detected, and the clinical effect was assessed. Results： After treatment, the total effective rates of treatment group and control group were 90.0% and 73.3% respectively, and the clinical effect of treatment group was better than that of the control group （P 〈0.05）. After treatment, the NIHSS scores in both groups were markedly decreased （ P 〈 0.05 ）, and the scores of treatment group were lower than those of the control group （ P 〈 0.05 ）. After treatment, the level of serum SOD of the treatment group was significantly increased （ P 〈 0.05 ）, and was higher than that of the control group （ P 〈 0.05 ）. Conclusion ： “Bushen Huoxue Decoction” can reduce the level of serum SOD in patients with acute cerebral infarction, so as to protect the nerve cells.
出处
《上海中医药大学学报》
CAS
2015年第1期27-29,共3页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
上海市卫生局中医药科研基金资助项目(2012L021A)
关键词
补肾活血汤
急性脑梗死
氧化应激
“Bushen Huoxue Decoction”
acute cerebral infarction
oxidative stress
