摘要
目的探究妊娠期甲状腺功能亢进症(甲亢)患者血清免疫含量变化,探讨其临床价值。方法选择妊娠期甲亢患者127例作为临床研究对象,记为试验组。选取同期入院的182例妊娠期非甲亢患者作为对照组。测量2组患者在妊娠不同阶段的甲状腺功能情况和TRAb(促甲状腺激素受体抗体)浓度,比较分析2组结果在同一时期的差异。结果整个妊娠过程中,试验组患者三碘甲腺原氨酸(T3)、四碘甲腺原氨酸(T4)水平均明显高于对照组,其妊娠中、晚期游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)浓度降低,妊娠早、中期TRAb阳性检出率(74.80%、80.31%)均明显高于对照组(35.16%、32.42%),差异有统计学意义(P<0.05)。结论妊娠期甲亢患者在整个妊娠过程中,T3、T4高水平表达,妊娠早、中期TRAb阳性率明显偏高,妊娠中、晚期FT3、FT4水平明显降低,提示妊娠期妇女应定时进行甲状腺功能检查,密切关注FT3、FT4水平及TRAb阳性率,切实做好早筛查,早治疗,避免不良妊娠结局的发生。
Objective To discuss the changes of immune function of patients with Graves disease and analyze the application values in clinic. Methods The average concentration of serum thyroid function and TSH receptor antibody（TRAb）during the pregnancy of 127 patients with Graves disease in the experiment group and 182 patients without Graves disease in the control group were detected respectively, compared the differences of two groups at the same period. Results The level of serum T3 and T4 of patients in the experiment group in all phases of pregnancy and the TRAb positive rate in the early and medium phase of pregnancy was significantly higher than that of control group, while the level of serum FT3 and FT4 of patients in the medium and late phase of pregnancy of experiment group were lower than the control group （1~〈0.05）. Conclusion There was a high level of serum T3 and T4 in all phases of pregnancy of patients with Graves disease, with a higher TRAb positive rate in the early and medium phase of pregnancy, a lower level of serum FT3 and FT4 in the medium and late phase of pregnancy. Pregnant women should be regularly thyroid hormone examination, especially the change of FT3 ,FT4 and TKAb, achieve early screening and early treatment to improve pregnancy outcome.
出处
《当代医学》
2015年第5期56-57,共2页
Contemporary Medicine
