摘要
目的探讨胃癌患者围手术期外周血T淋巴细胞亚群及NK细胞表达的临床意义。方法采用流式细胞仪检测69例胃癌患者术前及术后7天及35例健康者外周血T淋巴细胞亚群及NK细胞表达水平。结果健康者与胃癌患者对比、胃癌患者术后7天与术前对比、Ⅰ~Ⅱ期与Ⅲ~Ⅳ期胃癌患者对比,其外周血CD3＋、CD4＋、CD4＋/CD8＋及NK细胞表达水平较高,CD8＋较低,差异均有统计学意义（P〈0.05）。中等分化癌组与低等分化癌组比较无显著变化（P〉0.05）。结论胃癌患者免疫功能较低,术后1周有所提高;病理分期越晚免疫功能越差,肿瘤分化程度与机体免疫功能关系不明显。
Objective To research and analyze the expression levels of the T lymphocyte subsets and NK cells in the gastric cancer patients’ peripheral blood,and to explore its clinical significance.Methods Using flow cytometry to detect 69 cases of patients with gastric cancer before and after 7days and 35 cases of healthy peripheral blood T lymphocyte subsets and NK cells expression levels.Results Healthy subjects and patients with gastric contrast、seven days in patients after gastric surgery and pre-operative contrast,Ⅰ-Ⅱ phase andⅢ-Ⅳ period）in patients with gastric contrast,peripheral blood CD3＋,CD4＋,CD4＋/CD8＋,NK expression levels higher than the patients with gastric cancer,CD8＋lower than the patients with gastric cancer,there were statistically significant differences（P〈0.05）.Moderately differentiated carcinoma group showed no significant change in the group with low differentiated cancer（P〉0.05）.Conclusion Low immune function in patients with gastric cancer,postoperative one week maybe increase;the pathological staging the longer the worse immune function,degree of tumor differentiation is not obvious relationship with the body’s immune function.
出处
《福建医药杂志》
CAS
2015年第1期62-65,共4页
Fujian Medical Journal
