摘要
目的:探讨宫颈环形电切术(LEEP)治疗高级别宫颈上皮内瘤变(CINII、CINIII)中的安全性与有效性。方法:总结分析2008年1月至2008年12月在皖南医学院第一附属医院经LEEP治疗后87例高级别宫颈上皮内瘤变患者5年的随访资料,分析患者的病情转归。结果:随访5年内治愈85例(97.7%),复发2例(2.3%);二分类Logistic回归分析显示:年龄是术后复发的危险因素(P<0.05),累及腺体与否对术后复发无显著影响(P>0.05);5例术前无生育史者术后均自然受孕,受孕率为100%,无不良妊娠结局,均择期剖宫产分娩,5例因非意愿怀孕行人工流产术,1例稽留流产。结论:LEEP治疗CINII、CINIII是安全、有效的,不影响妊娠结局。TCT联合HPV检测是术后随访的可靠方法。
AIM：To evaluate the security and effectiveness of loop electrosurgical excision procedure （LEEP） for high-grade cervical intraepithelial neoplasia （CINⅡ,CINⅢ）.METHODS：To analyze the clinical information of 87 patients whose pathology diagnosed as CINⅡ,CINⅢ through LEEP in the First Affiliated Hospital of Wannan Medical College between January 2008 and December 2008 for 5 years and their disease outcome.RESULTS：During 5 years follow-up,85 cases cured （97.7%） and 2 cases recurred （2.3%）; Binary logistic regression analysis showed that age was the risk factor of recrudescence（P〈0.05）,but no significant relationship between gland involvement and recrudescence of CINⅡ,CINⅢ after LEEP（P〉0.05） ; 5 patients who had no fertility history of preoperative owned natural conception.The conception rate was 100%.All of them had cesarean delivery（1 case/twice）,without adverse pregnancy outcomes.5 cases received induced abortion,who did not have fertility desires pregnancy.1 case had missed abortion.CONCLUSION：LEEP is a secure and effectiveness treatment to CINⅡ,CINⅢ and does not affect the pregnancy outcome.TCT combined with HPV test is a reliable method to postoperative follow-up.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2014年第12期1411-1415,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
宫颈环形电切术
宫颈上皮内瘤变
随访
妊娠结局
cervical intraepithelial neoplasia
loop electrosurgical excision procedure
follow-up
pregnancy outcome
