摘要
目的探讨奥曲肽联合埃索美拉唑钠治疗肝硬化并发食管胃底静脉曲张破裂出血的疗效。方法选取2013年6月~2014年6月我院应用奥曲肽联合埃索美拉唑钠治疗的肝硬化并发食管胃底静脉曲张破裂出血患者32例,设为观察组。另选择2012年6月~2013年6月应用垂体后叶素、硝酸甘油及三腔两囊管治疗的肝硬化并发食管胃底静脉曲张破裂出血患者26例（对照组）。结果用药后24 h内观察组的总有效率达81.25%,对照组的总有效率达69.23%,两组疗效比较差异有统计学意义（P〈0.05）。观察组患者的止血时间（12.63±2.51）h、住院时间（8.6±1.3）d均短于对照组的（22.48±5.23）h、（10.3±2.4）d,观察组患者平均输血量（289.4±32.1）m L明显少于对照组的（531.8±63.9）m L,观察组患者治疗1周内再出血率3.1%明显低于对照组1周内再出血率11.5%,差异具有统计学意义（P〈0.05）。观察组仅1例患者出现恶心、呕吐,减慢静脉滴注速度后好转。对照组出现胸闷2例、心悸、头晕、乏力感1例,腹痛、便意、恶心2例,上述症状均对症处理后缓解消失。结论奥曲肽联合埃索美拉唑钠可以提高肝硬化并发食管胃底静脉曲张破裂出血的疗效,止血成功率高,安全性好,值得推广和应用。
Objective To investigate the effect of octreotide combined esomeprazolesodium in the treatment of liver cirrhosis complicated with esophageal varicealbleeding. Methods From 2013 June to 2014 June in our hospital application of octreotide combined with esomeprazole sodium in the treatment of liver cirrhosis complicated with esophageal variceal bleeding in 32 patients, for the observation group. From 2012 June to June 2013 the application to pituitrin,nitroglycerin and three cavity two capsule pipe treatment liver cirrhosis complicated with esophageal variceal bleeding in 26 patients, for the control group. Results The total effective rate of observation group within 24 h after treatment was 81.25%, the total effective rate of control group was 69.23%, compare the effect of two groups, the difference was statistically significant（P〈0.05）. The hemostatic time of observation group were（12.63±2.51） h, hospitalization time（8.6±1.3） d, respectively, were shorter than those of control group（22.48±5.23）h,（10.3±2.4）d,the mean blood transfusion group were（289.4±32.1）m L, significantly less than the control group（531.8±63.9）m L, the patients in the observation group were treated within 1 weeks of rebleeding rateof 3.1%,was significantly lower than the control group（11.5%）, the difference was statistically significant（P〈0.05）. The observation group only 1 patients had nausea, vomiting, slow down the speed of intravenous infusion after the turn for the better. The control group of 2 cases of heart palpitations, chest tightness, dizziness, fatigue in 1 cases, 2 cases of abdominal pain, nausea, meaning, to alleviate these symptoms were disappeared after symptomatic treatment. Conclusion Octreotide combined with esomeprazole sodium can improve the liver cirrhosis complicated with esophageal variceal bleeding, hemostasis success rate high, the security is good, worthy of promotion and application.
出处
《中国现代医生》
2015年第4期20-22,共3页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2010KYB099)
