摘要
目的 探讨急性颅脑损伤程度与局部脑血流量（rCBF）、局部脑血容量（rCBV）、血液通过组织的平均通过时间（MTT）之间的相关性,为早期诊断和预后评价提供可能的依据.方法 本次研究纳入急性颅脑损伤患者67例.根据格拉斯哥昏迷评分（GCS）分为轻型组、中型组和重型组.入院进行320排螺旋CT的灌注成像（CTP）检测rCBF、rCBV和MTT,分析颅脑损伤程度与rCBF、rCBV和MTT之间的关系.随访患者6个月后的预后情况,与rCBF、rCBV和MTT进行相关分析.结果 重型组rCBV与rCBF明显低于轻型组,而重型组MTT明显要高于轻型组,显示出与rCBF和rCBV相反的变化趋势（P＜0.05）.rCBV与格拉斯哥预后评分（GOS）呈明显的正相关（P＜0.01）,MTT与GOS呈明显的负相关,而rCBF与GOS并无明显的相关性.结论 rCBF、rCBV和MTT与急性颅脑损伤严重程度和患者的预后存在相关性,在评估急性颅脑损伤严重程度及预后时有一定的参考价值.
Objective To investigate the relevance between the seriousness of acute brain injury and regional cerebral blood flow （rCBF）,regional cerebral blood volume （rCBV） or mean transition time （MTT） ; provide a possible method for the early diagnose and prognostic evaluation.Methods This study included 67 patients of acute brain injury and they were divided into mild,moderate and severe groups based on their glasgow coma scale （GCS） scores.They were examined to detect rCBF,rCBV and MTT by computed tomography perfusion （CTP） imaging after admittcd to hospital.The prognoses of them after 6 months of follow-up were also recorded.The relations between the prognosis and rCBF,rCBV or MTT were analyzed.Results rCBV and rCBF of severe group were significantly lower than the mild group （P 〈 0.05）,and MTT of severe group was significantly higher than that of the mild group （P 〈 0.05）.The rCBV and the glasgow outcome scale （GOS） scores were significantly positively correlated （P 〈 0.01）,and MTT was significantly negatively correlated with the GOS score （P 〈 0.01）.Whereas there was no correlation between rCBF and the COS score.Conclusion rCBF,rCBV and MTT were significantly correlated with the severity as well as the prognosis of patients with acute brain injury and they might be used as potential indicators of the severity and prognosis.
出处
《中华神经外科杂志》
CSCD
北大核心
2015年第1期54-56,共3页
Chinese Journal of Neurosurgery
关键词
颅脑损伤
局部脑血流量
局部脑血容积
平均通过时间
Craniocerebral trauma
Regional cerebral blood flow
Regional cerebral blood volume
Mean transit time
