摘要
目的探讨上海长海医院自制川芎口服制剂头痛灵口服液在冠脉介入治疗中预防对比剂肾病(CIN)的疗效及安全性。方法将2014年4月—6月住院行择期冠脉介入的患者随机分为川芎组(113例)和对照组(109例),两组均常规水化治疗,川芎组在水化基础上加用川芎口服制剂头痛灵口服液,比较两组术后CIN的发生及川芎相关药物不良反应的情况。结果冠脉介入术后发生CIN者川芎组有5例(4.42%),对照组有13例(11.9%),两组间差异有统计学意义(χ2=4.191,P<0.05)。川芎组患者均未出现川芎相关的药物不良反应。发生CIN的18例患者在水化、碱化尿液治疗后均获恢复。结论在水化治疗基础上口服川芎制剂对冠脉介入术后CIN的发生有明显预防作用,且无明显不良反应。
Objective To evaluate the safety and efficacy of oral Changhai Hospital self-made preparation of rhizoma chuanxiong in preventing contrast-induced nephropathy（CIN） in patients undergoing selective percutaneous coronary intervention（PCI）. Methods During the period from April 2014 to June31, 2014, a total of 222 patients with cardiac disorders were admitted to Changhai Hospital to receive selective coronary intervention. The patients were randomly divided into the study group（n = 113） and the control group（n = 109）. Routine hydration therapy with 0.9% sodium chloride solution was performed in the patients of both groups, and additional oral preparation of rhizoma chuanxiong and oral liquid of headache pill were given to the patients of the study group. The incidences of CIN were compared between the two groups, and the chuanxiong-related side effects were analyzed. Results The incidence of CIN occurring after PCI in the study group and the control group was 4.42%（n = 5） and 11.9%（n = 13） respectively, and the difference between the two groups was statistically significant（χ2= 4.191, P 0.05）. No chuanxiong-related side effects occurred. After hydration therapy and urine alkalization treatment all the 18 patients with CIN returned to normal status. Conclusion On the basis of hydration therapy, oral preparation of rhizoma chuanxiong can effectively prevent postoperative CIN from happening in patients undergoing selective percutaneous coronary intervention. Besides, oral preparation of rhizoma chuanxiong has no obvious side effects.
出处
《介入放射学杂志》
CSCD
北大核心
2015年第2期102-105,共4页
Journal of Interventional Radiology
关键词
冠脉介入
对比剂肾病
川芎
口服制剂
percutaneous coronary intervention
contrast-induced nephropathy
rhizoma chuanxiong
oral preparation
