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HPIP蛋白与恶性肿瘤关系的研究进展

Progress of the relationship between HPIP and cancer
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摘要 随着肿瘤分子生物学的飞速发展,分子靶向治疗已成为肿瘤治疗方法中最具前景的研究领域,分子靶点的研究也早已成为医学界关注的热点。人造血相关的PBX相互作用蛋白质(HPIP)是一种新型的支架蛋白。近年来根据相关文献报道,HPIP与肿瘤生的长、增殖和转移密切相关,有可能成为肿瘤治疗的新靶点。本文总结了HPIP在恶性肿瘤发展中的作用及其相关机制的研究进展。 With the rapid development of tumor molecular biology,molecular targeted therapy has become the most promising treatment of cancer and the study of molecular targets has been to be a hot topic for a long time. Remarkably,hematopoietic Pbx-interaction protein（ HPIP）,a microtubule-binding protein,is a novel scaffolding protein. To date,according to the relevant literature,HPIP is closely associated with tumor growth,proliferation and metastasis. HPIP may be a new target for cancer therapy in the future.We review a representative set of resent studies and summarizes the progress of mechanisms and significance of HPIP in the development of malignant tumors.
作者 王倩 欧阳学农 陈雄
机构地区 福建中医药大学福州总医院临床医学院 南京军区福州总院肿瘤内科
出处 《临床肿瘤学杂志》 CAS 2015年第1期83-86,共4页 Chinese Clinical Oncology
基金 国家自然科学基金青年基金资助项目(81302067)
关键词 造血相关的PBX相互作用蛋白质基因(HPIP) 分子靶向治疗 进展 Hematopoietic PBX-interacting protein Molecular targeted therapy Progress
分类号 R73 [医药卫生—肿瘤]
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参考文献20

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二级参考文献104

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临床肿瘤学杂志
2015年 第1期

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