摘要
目的 探讨氨基末端脑钠肽前体（NT-proBNP）与冠状动脉病变的相关性.方法 入选笔者医院2012年6月～2014年2月诊断为急性ST段抬高型急性心肌梗死（ST-elevation myocardial infarction,STEMI）患者157例,根据患者血中NT-proBNP水平分为NT-proBNP正常组（NT-proBNP ＜780pg/ml） 78例、NT-proBNP升高组（NT-proBNP＞ 780pg/ml） 79例.统计患者入院基本临床资料,所有患者均检测肌钙蛋白（cTnⅠ）、空腹血糖（FPG）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）,根据冠状动脉狭窄直径≥50％累及左前降支（LAD）、左回旋支（LCX）、右冠状动脉（RCA）或左主干（LM）分为单支、双支（累及左主干为双支病变）及3支病变组,根据Gensini积分标准对每位患者冠状动脉病变进行评分.计量资料采用均数±标准差（（x±s）表示,组间比较采用两独立样本t检验,计数资料采用率表示,组间比较用x2检验,NT-proBNP水平与冠状动脉Gensini积分相关性采用线性相关分析.结果 与NT-proBNP正常组相比,NT-proBNP升高组患者冠状动脉病变情况在总体上差异有统计学意义（P =0.000）,以冠状动脉无病变组作为对照组,单支病变组、两支/左主干病变组和3支病变组与对照组相比,差异均有统计学意义（P=0.004,P=0.000,P=0.000）;NT-proBNP升高组患者平均冠状动脉病变支数更多（1.22±0.84 vs2.08±0.82,P=0.000）,Gensini积分更高（24.83±22.31 vs 54.60±29.13,P=0.000）;NT-proBNP与Gensini积分存在相关关系（r=0.648,P=0.000）.结论 冠状动脉病变程度与NT-proBNP存在一定关系,可以用血中NT-proBNP水平预测冠状动脉病变程度.
Objective To explore the correlation between NT - proBNP and coronary arterty lesions. Methods Totally 157 patients were diagnosed coronary heart disease （CHD） from June 2012 to February 2014 in our hospital. Patients were divided into NT - proBNP normal group （78 cases） or NT- proBNP elevatory group（79 cases） according to the level of NT -proBNP. 157 patients diagnosed of CHD were studied basic clinical charateristics, cTnI, fasting blood glucose,total cholesterol, triglycerides, high density lipoprotein choles- terol and low density liporotein cholesterol were determined in all the patients. All patients were divided into none vessel lesions, 1 vessel lesions,2 vessels lesions or large main vessel lesions,3 vessels lesions groups according to stenosis of major vessels≥50%. We evaluated every patient coronary lesions according to Gensini score criteria. The quantitative data were expressed by x ± s and the qualitative data were expressed by rete. The quantitative data comparison between the groups was used independent - samples t test and the quantitative da- ta comparison between grounps was used ehi - square test, and the correlation between NT - proBNP and coronary artery lesions Gensini score was used linear correlation analysis. Results On the whole, there is statistical significance （P = 0. 000） in Coronary artery lesions in patients with NT -proBNP normal group and NT -proBNP group. Compared with none coronary atery lesions, 1 vessel lesions,2 or left main vessels lesions and 3 vessel lesions have statistical significance （ P = 0. 004, P = 0. 000, P = 0. 000 ）. Compared with NT - proBNP normal group,the average coronary artery lesions and Gensini score of every patients in SAP group is higher（ P 〈 0.05 ）. NT - proBNP was correlated with the Gensini score. Conclusion There is correlation between NT - proBNP levels and coronary artery lesions, and the NT - proBNP levels can be used to predict the severity of coronary artery lesions.
出处
《医学研究杂志》
2015年第1期47-50,138,共5页
Journal of Medical Research
基金
国家自然科学基金资助项目(81270184)
