摘要
新生儿肺透明膜病(HMD)是早产儿呼吸困难和死亡最常见的原因,由于其病死率高、后遗症多,救治此类患儿仍是新生儿科医师面临的严峻挑战。HMD发病机制十分复杂,尚未完全阐明。目前认为宫内感染与HMD发病密切相关,孕妇妊娠期间发生感染,胎儿暴露于炎性环境,引起胎儿炎症反应,导致大量炎性细胞聚集,并释放多种炎性介质,炎性介质之间在不同环节上相互作用,形成了非常复杂的炎症网络,感染后多种效应细胞及炎症介质可能是造成HMD发病的"中心环节",一方面过度的炎症刺激可能阻碍肺泡化进程和肺微血管发育,导致肺损伤和HMD,另一方面适度的炎症反应可能促进肺表面活性物质合成,促进肺成熟。
Hyaline membrane disease（ HMD） is the most common cause for dyspnea and death of premature infants,and due to its high case fatality rate and various sequelae,it＇s still a severe challenge for physicians of neonatology department to treat children with HMD. The pathogenesis of HMD is very complex and currently has not been well known. At present,it＇s believed that intrauterine infection is closely related to the attack of HMD; if a pregnant woman is infected during pregnancy,the fetus will be exposed to an inflammatory environment,leading to inflammatory response of the fetus and the accumulation of large amounts of inflammatory cells,which will release various kinds of inflammatory media; such inflammatory media interacts with each other at different links to form a very complex inflammation network,and various kinds of effector cells and inflammatory media after inflection may be the＂central links＂causing HMD,the mechanism is： on one hand,excessive inflammatory stimulation may impede the process of alveolarization and the growth of pulmonary capillaries,resulting in lung injury and HMD; on the other hand,moderate inflammatory response may promote the synthesis of pulmonary surfactant（ PS）,which promotes the maturity of lung.
出处
《医学综述》
2015年第3期448-451,共4页
Medical Recapitulate
基金
福建省自然科学基金(2014J01429)
关键词
宫内感染
新生儿肺透明膜病
炎症
炎症介质
Intrauterine infection
Hyaline membrane disease
Inflammation
Inflammatory medium
