摘要
目的总结分析我院血栓性血小板减少性紫癜（TTP）患者临床表现,实验室特点及治疗反应,以提高TTP诊断水平和治疗效果。方法对我院2008年6月～2013年2月期间诊断为TTP的7例患者进行基础资料回顾性分析。7例研究对象中男性5例,女性2例。年龄16～72岁。民族：汉族4人,维吾尔族2人,哈萨克族1人。临床表现均出现发热、不同程度头痛、神志障碍、抽搐、黄疸、贫血和血小板减少及和尿素氮及肌酐等指标升高现象。病因学分析,特发性TTP 4例,占57.1%;继发性TTP 3例,占42.9%,分别为与系统性红斑狼疮相关1例、感染相关1例、肿瘤相关1例。结果经过血浆置换、间断输血浆及使用大剂量激素等综合性治疗后,7例患者中6例好转,1例死亡。结论尽早使用血浆置换辅以大剂量糖皮质激素是TTP的首选治疗方法,它能够降低患者的病死率,效果肯定。
Objective To investigate clinical and laboratory features of thrombotic thrombocytopenic purpura（ TTP） and its prognosis in order to improve the diagnosis and treatment of TTP. Methods seven TTP patients admitted to our hospital from 2008-06 to 2013-02 were retro-spectively analyzed. 7 cases of TTP patients,5 case of male,2 females,age 16 ~ 72 years. 4 case of the Han nationality,2 case of in Uigur,and Kazakh 1,which had fever、headache、metal-obstacle、convulsion and hemolytic anemia,thrombocytopenia and neurologic abnormalities. Major etiologic factors were acquired thrombotic thrombocytopenic purpura were idiopathic TTP（ 57. 1%）. Secondary TTP（ 42. 9%） associated with SLE、infection and cancer. Results fresh plasma add a large dose of hormone on Treatment of thrombotic thrombocytopenic purpura（ TTP）. 6 patients survival,one patient was dead. Conclusion PE is good choice for TTP reduce the mortality.
出处
《血栓与止血学》
2015年第1期45-47,共3页
Chinese Journal of Thrombosis and Hemostasis
