摘要
目的对近年来薯蓣皂苷元及其衍生物的构效关系研究进展进行综述,为薯蓣皂苷元的进一步研究提供思路。方法查阅了近10年关于薯蓣皂苷元衍生物研究的中外文献资料,对其构效关系进行了比较全面地综述。结果许多国内外学者针对不同生理活性对薯蓣皂苷元进行结构修饰,开发出一批具有高效低毒的先导化合物。结论薯蓣皂苷元衍生物具有良好的开发前景,应加强其衍生物与构效关系的研究。
Objective To review the research progress of the studies of diosgenin derivatives and provide a theoretical basis for diosgenin research and development.Methods Based on domestic and foreign literatures published in recent 10 years,the diosgenin and its derivatives were reviewed.Results Domestic and foreign researchers choose diosgenin and optimize its chemical structures in order to develop a number of new derivatives with better pharmacological activities.Conclusions Diosgenin derivatives are promising for further development.Diosgenin and its derivatives should be paid more attention to the research.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2015年第2期154-160,共7页
Journal of Shenyang Pharmaceutical University
关键词
薯蓣皂苷元
结构修饰
构效关系
抗肿瘤
diosgenin
structure modification
structure-activity relationships
antitumor
