摘要
目的:观察体外培育牛黄(CCB)对老年慢性阻塞性肺病急性加重期(AECOPD)患者的临床疗效及改善血液流变性的作用。方法:102例AECOPD患者,按随机对照原则分为对照治疗组(n=48,给予抗生素及支气管扩张剂等治疗)、CCB治疗组(n=54,在对照治疗组基础上联合口服CCB 0.15g/次,2次/日)。均在治疗5天后统计分析两组临床疗效及血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT)和血液流变学指标变化,并继续上法治疗直至患者出院,比较两组住院时间及药物反应。结果:CCB治疗组临床显效率和总有效率分别为37.04%(20/54)及92.59%(50/54),显著高于对照治疗组20.83%(10/48)和70.83%(34/48)(均P<0.05)。两组治疗5天后外周血hs-CRP水平和PCT水平均较同组治疗前显著下降(P<0.05),CCB治疗组治疗后以上两指标下降更显著(P<0.05)。两组治疗后全血高切和低切表观黏度、血浆黏度及纤维蛋白原水平均较治疗前明显下降(P<0.05),CCB治疗组下降更明显(P<0.05)。CCB治疗组住院天数为10.24±1.51天,明显少于对照治疗组14.01±1.84天(P<0.05)。CCB治疗组治疗期间未观察到严重不良反应。结论:常规用药联合CCB治疗老年AECOPD可提高疗效、缩短疗程,并改善血液高黏滞状态,有重要临床应用价值。
Objective：To observe the clinical effect of vitro cultured calculus bovis（CCB）in the elderly acute exacerbation in chronic obstructive pulmonary disease（AECOPD）patients and the change in the hemorheology.Method：102patients with AECOPD were involved.CCB treatment group（n= 54）received CCB orally 0.15 g 2times per day for 5days,while control treatment group（n= 48）was given a routine treatment（antibiotic therapy and bronchodilators）.The symptoms,hospitalization time,hs-CRP,PCT and hemorheology were observed.Results：After 5days treatment,the significant effective rate and the total effective rate in CCB treatment group was 37.04%（20/54）and 92.59%（50/54）,which was significantly higher than that of the control treatment group 20.83%（10/48）and 70.83%（34/48）（P〈0.05）.The peripheral blood hs-CRP level and PCT level in both CCB treatment group and control treatment group were significantly decreased compared with that before treatment（P〈0.05）,and the peripheral blood hs-CRP level and PCT level in CCB treatment group decreased more significantly than that in the control group compared with before treatment（P〈0.05）.The blood viscosity 300s-1,blood viscosity 1s-1,plasma viscosity and fibrinogen lever were significantly decreased in CCB treatment group and control treatment group after treatment and were significantly deceased in CCB treatment group compared with control treatment group（P〈0.05）.Conclusion：CCB is a safe and efficient therapy in the treatment of elderly AECOPD which can effectively alleviate the symptoms,shorten the course and improve the state of blood high viscosity.
出处
《微循环学杂志》
2015年第1期29-33,共5页
Chinese Journal of Microcirculation
关键词
体外培育牛黄
慢性阻塞性肺病急性加重期
降钙素原
血液流变学
Vitro cultured calculus bovis； Acute exacerbation in chronic obstractive pulmonary disease； Procalcitonin； Hemorheology
