血清内脏脂肪组织丝氨酸蛋白酶抑制因子水平与冠心病患者危险因素及预后的关系被引量：5

The association between serum Vaspin level and risk factor and prognosis of coronary atherosclerotic heart diseases

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摘要目的探讨内脏脂肪组织丝氨酸蛋白酶抑制因子(Vaspin)水平与冠心病(CVD)的相关性。方法随机选取在上海市第十人民医院心内科就诊并行冠状动脉造影的191例被试,其中有88例确诊CAD的患者,103例为阴性。检测常规生化、心肌标志物、Vaspin和脂连素(adiponectin),通过超声心动图了解心脏功能,并对该组人群进行2年的随访,研究其与基线临床参数和Vaspin水平之间的关系。结果 CAD组Vaspin水平显著低于非CAD组[0.18(0.09,0.46)ng/ml vs 0.43(0.20,1.81)ng/ml,P<0.001];经过2年的随访,共有41人49次心脏不良事件(MACE)发生,MACE组基线Vaspin显著低于无MACE组[0.23(0.07,0.69)ng/ml vs 0.22(0.11,0.46)ng/ml,P=0.031];在所有MACE人群中Vaspin平均水平随着MACE的严重性加剧而降低,最低为死亡患者[(0.18±0.08)ng/ml];最后,左室收缩功能下降的患者基线Vaspin水平显著低于收缩功能上升者[0.18(0.13,0.59)ng/ml vs 0.53(0.41,0.25)ng/ml,P=0.001]。结论 CAD患者血清Vaspin水平较低,2年内发生MACE的患者基线Vaspin水平较低,心功能下降者基线Vaspin水平较低。 Objective To explore the association between the visceral adipose tissue-derived serine protease inhibitor （Vaspin） level and coronary atherosclerotic heart disease （CAD）. Method A total of 191 patients angiographically proved were randomly enrolled in this study, including 88 patients with CAD and 103 subjects without CAD. Circulating Vaspin, adiponectin, clinical parameters were assayed. The heart function was evaluated according to the eehocardiography. Enrolled subjects were followed for 2 years. The relationship between serum Vaspin concentration of baseline and the outcomes of CAD was evaluated. Result The Vaspin concentration in CAD patients was significantly lower than that in non-CAD patients [ 0. 18 （0.09,0.46） ng/ml vs 0.43 （0.20,1.81） ng/ml, P〈0. 001 ]. After 2-years＇ follow-up, there were 49 times major adverse cardiac events occurred with 41 patients. Vaspin level in MACE patients was dramatically lower than that in non-MACE patients [ 0.23 （0.07,0.69） ng/ml vs 0. 22 （0.11,0.46） ng/ml, P= 0.031 ]. The patients who had the lowest concentration of baseline Vaspin were attacked by cardiac death[ （0.18±0.08） ng/ml]. Baseline Vaspin level in the patients whose left ventricular ejection fraction decreasedwas significantly lower than that in the patients whose LVEF rose up[0.18 （0.13,0.59） ng/ml vs 0.53 （0.41,1.25） ng/ml, P=0. 001 ]. Conclusion Circulating Vaspin is lower in CAD patients. Patients who occurred MACE and had decreased LVEF have lower baseline Vaspin level during 2- years＇ follow-up.

作者苏杨明强李海玲彭文辉张毅魏毅东徐亚伟

机构地区上海市第十人民医院心血管内科

出处《中国心脏起搏与心电生理杂志》 2015年第1期45-49,共5页 Chinese Journal of Cardiac Pacing and Electrophysiology

关键词心血管病学冠心病内脏脂肪组织丝氨酸蛋白酶抑制因子主要心脏不良事件左室射血分数 Cardiology Coronary atherosclerotic heart disease Visceral adipose tissue-derived serine protease inhibitor Major adverse cardiovascular events Left ventricular ejection fraction

分类号 R541.4 [医药卫生—心血管疾病]

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