摘要
视网膜变性疾病（RDD）虽然发病背景不同,但有着共同的病理基础,无论是遗传因素还是年龄相关因素引起的RDD,最终均导致视功能的严重损害甚至致盲,因此,RDD是发达国家难治性的致盲眼病,其共同表现是视网膜光感受器细胞的变性或丧失.目前临床上虽然采取很多措施以期望能够减缓其进展,但是光感受器细胞一旦丧失将无法再生,特别是目前严重视网膜色素变性（RP）和干性年龄相关性黄斑变性（AMD）等病变,尚无任何有效的治疗方法.人工视觉假体作为能够代替变性或死亡视网膜光感受器细胞功能的一类人工器官引起了研究者的极大兴趣,在近20年的研究中取得很大进展,一些代表性产品已通过了美国FDA的批准进入临床转化阶段,为RDD患者的视功能重建带来了新希望.中国目前也有研究人员积极参与相关研究,建议有志于参与这方面研究的工作者充分了解国内外相关领域的研究现状和研究背景,并进行多学科的联合研究,尤其是在该研究成果的临床转化方面作出贡献.
Although retinal degenerative diseases （RDD） has different pathogenesis backgrounds,the pathological basis is quite close.Either inheritance RDD or age-related RDD remains the largest cause of untreatable blindness in developed countries.Encompassing a range of causes ultimately result in the loss of the sensory cells of the retina and photoreceptors.Many therapeutic strategies aim to slow down the progression of RDD.However,it is well known that once photoreceptors are lost,they can not regenerate.So the treatment is currently unavailable to severe patients with retinal pigmentosa （RP） and dry age-related macular degeneration （AMD）.A visual prosthetic device appears to offer new hope in replacing the function of degenerating or dead photoreceptor neurons and relevant studies are making progress.Some visual prosthetic devices have been approved by American FDA and entered clinical trials.Fewer researchers in China are participating in relevant work.I suggest that our researchers interested in artificial visual prosthesis should have a strong understanding of the current research and multi-disciplinary combination and moreover attend the clinical translational study of artificial visual prosthesis for RDD.
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2015年第2期97-101,共5页
Chinese Journal Of Experimental Ophthalmology
