摘要
目的 探讨无淋巴结转移胃癌患者的临床病理特征及预后影响因素.方法 回顾性分析天津医科大学总医院2004年1月至2013年12月间300例接受胃癌根治手术并且术后病理诊断为无淋巴结转移胃癌患者的临床病理资料,并对影响预后因素采用Kaplan-Meier法和Log-rank检验进行单因素分析,应用COX比例风险回归模型进行多因素分析.结果 本组300例无淋巴结转移胃癌患者术后1、3、5年总体生存率分别为80%、69%和63%.单因素分析结果显示肿瘤大小、组织学类型及浸润深度与患者预后相关(均P <0.05);多因素分析结果显示肿瘤大小(RR:1.800,95% CI:1.120 ~2.891,P=0.015)、组织学类型(RR:1.982,95% CI:1.291~3.042,P=0.002)和浸润深度(RR:1.464,95%CI:1.213 ~1.767,P=0.000)是影响本组胃癌患者预后的独立因素.结论 对于无淋巴结转移的胃癌患者,肿瘤大小、组织学类型和浸润深度是影响预后的重要因素.
Objective To investigate the clinicopathological characteristics and prognosis in patients with node-negative gastric cancer.Methods Between January 2004 and December 2013,clinicopathological characteristics of 300 patients with node-negative gastric cancer who underwent radical gastrectomy in Tianjin Medical University General Hospital were retrospectively analyzed.Results The 1-,3-,and 5-year overall survival rates for patients with node-negative gastric cancer was 80%,69% and 63% respectively.The univariate analysis showed that tumor size,histologic type and depth of invasion had significant effects on the survival (P 〈 0.05).Multivariate analysis for these factors showed that tumor size (RR:1.800,95 % CI:1.120-2.891,P =0.015),histologic type (RR:1.982,95 % CI:1.291-3.042,P =0.002) and depth of invasion (RR:1.464,95% CI:1.213-1.767,P =0.000) were independent prognostic survival factors.Conclusions Tumor size,histologic type and depth of invasion are important prognostic factors of patients with node-negative gastric cancer.
出处
《中华普通外科杂志》
CSCD
北大核心
2015年第2期89-91,共3页
Chinese Journal of General Surgery
基金
天津市应用基础及前沿技术研究计划基金资助项目(09JCYBJC10200)
关键词
胃肿瘤
淋巴转移
预后
病理学
临床
Stomach neoplasms
Lymphatic metastasis
Prognosis
Pathology,clinical