摘要
目的探讨鞍区非垂体瘤病变的临床诊治特征。方法回顾性分析156例鞍区非垂体瘤病变的临床资料,囊性病变86例、炎性病变4例、良性肿瘤56例和恶性肿瘤10例。临床表现以头痛(50.6%)和视野缺损(41.7%)最常见,内分泌改变以皮质醇增高(32.7%)和泌乳素增高(20.5%)最常见。均行手术治疗。结果术后新发一过性尿崩13例,电解质紊乱8例,垂体功能改变3例。术后头痛与视觉症状缓解率分别为84%和73%,皮质醇增高和泌乳素增高缓解率分别为100%和77%。平均随访35个月,总体复发率为8.2%(13/156),病死率为0.6%(1/156)。结论鞍区非垂体瘤病变,术前鉴别诊断较困难,有一定误诊率。治疗手段以手术治疗为主,术后症状缓解明显,并发症少;术后复发率低,预后好。
Objective To discuss the clinical f eatures and diagnosis and treatment of non-pituitary sellar lesions. Methods The clinical data of 156 patients with non-pituitary lesions were analyzed retrospectively. There were cystic lesions in 86 cases,inflammatory lesions in 4, benign neoplasms in 56 and malignancies in 10. The most common symptoms were headache（50.6%） and visual field defect（41.7%）, the most common pituitary dysfunctions were hypercortisolism（32.7%） and hyperprolactinemia（20.5%）.All the patients underwent surgery treatment. Results There was transient diabetes insipidus in 13 patients, electrolyte disturbance in 8and pituitary dysfunction in 3 after operation. The remission rates of headache, visual symptoms, hypercortisolism, hyperprolactinemia were 84%, 73%, 100% and 77% respectively. After a mean follow-up of 35 months, the total recurrence rate was 8.2%（13/156）, the mortality rate was 0.6%（1/156）. Conclusions The differential diagnosis of sellar non-pituitary lesions is difficult, with a certain misdiagnosis rate. Surgery is the main treatment for the lesion with significant relief of symptoms and fewer complications. The prognosis is good and recurrence rate is low after operation.
出处
《中国微侵袭神经外科杂志》
CAS
2015年第2期64-67,共4页
Chinese Journal of Minimally Invasive Neurosurgery
关键词
鞍区病变
非垂体瘤病变
垂体功能障碍
sellar lesions
non-pituitary lesions
pituitary dysfunction
