摘要
目的：初步了解本地区孕前健康体检男性精液质量现状及其影响因素,为制定有效干预措施提供依据。方法：对符合纳入标准的687例本地孕前男性进行问卷调查,并进行精液质量分析。结果：精子浓度中位数为63.30×10^6/ml,95%CI范围为（19.88-119.0）×106/ml;a级精子百分率中位数为33.03%,95%CI范围为（19.38-55.05）%;（a＋b）级精子百分率中位数为52.08%,95%CI范围为（39.53-69.37）%;畸形精子百分率中位数为91.75%,95%CI范围为（69-100）%;精浆弹性蛋白酶中位数为195.55 ng/ml,95%CI范围为（76.16-3 330.38）ng/ml;精浆锌中位数为7.62μmol/L,95%CI范围为（1.50-23.45）μmol/L;UU阳性率42.4%,CT阳性率0.3%,加德纳菌（GV）阳性率2.4%;配偶有不良妊娠史精子DNA碎片指数（DFI）中位数为20.25%,95%CI范围为（2.15-68.25）%。多因素Logistic回归分析表明：有久坐习惯及精神压力大是精子活力降低的独立危险因素,OR值分别为1.772、1.567,95%CI分别1.211-2.592、1.081-2.27。结论：南京地区孕前男性精子质量不容乐观,改变不良习惯、减轻精神压力可能有助于改善精子质量。
Objective： To investigate the semen quality and its influencing factors in preconception males in Nanjing area so as to provide some evidence for working out effective intervention measures. Methods ： Totally 687 men receiving preconceptional physi- cal examination were enrolled in this study. A questionnaire survey was conducted among the subjects along with an analysis of their se- men quality. Results ： The median of sperm concentration was 63.3 × 10^6/ml （95% CI [19.88 - 119 ] × 10^6/ml）. The median of grade a sperm was 33. 03% （95% CI [19.38-55.05]%）, that of grade a ＋ b sperm was 52. 08% （95% CI [39.53-69.37]%）, and that of teratosperm was 91.75% （95% CI [69 - 100]% ）. The median concentration of seminal plasma PMN-elastase was 195.55 ng/ml （95% CI[76.16 - 3 330.38 ~ ng/ml） and that of seminal plasma zinc was 7.62 μmol/L （95% CI[1.5 - 23.45 ] μmol/L）. The positive rates of Ureaplasma urealyticam （UU）, Chlamydia trachomatis （CT）, and Gardnerella vaginalis （GV） were 42.4% , 0.3% , and 2.4% , respectively. The median of sperm DNA fragmentation index （DFI） of those whose wives had a history of adverse pregnancy was 20.25% （95% CI [2.15 -68.25] % ）. Multivariate logistic regression analysis suggested that mental stress （ OR 1. 567, 95% CI [1.081 - 2.27 ] ） and sedentariness （ OR 1. 772, 95% CI [1.211 - 2. 592]） were independent risk factors for asthenospermia. Conclusion ： The sperm quality of preconception males in Nanjing area is not encouraging, and it can be improved by changing undesirable lifestyle and reducing mental stress.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2015年第2期144-148,共5页
National Journal of Andrology
关键词
孕前
精液质量
影响因素
调查
preconception
semen quality
influencing factors
investigation
