摘要
目的:探讨Notch家族蛋白在银屑病发病机制中的作用。方法:收集58例银屑病患者皮损组织病理标本为患者组,同期收集28例表皮痣组织病理标本为对照组,采用免疫组化法检测Notch信号受体、配体(Notch1-4、DLL1、3、4和Jagged1、2)在患者组和对照组皮损标本中的定位及表达。结果:1Notch1、2、3、4,Jagged1、2,DLL1、3、4在银屑病患者皮损表皮中的表达水平较对照组皮损表皮中增强,两组之间差异有统计学意义(P<0.05);2Notch1、2、3、4,Jagged1,DLL1、3在银屑病患者皮损真皮中的表达水平较对照组皮损真皮中增强,两组之间差异有统计学意义(P<0.05);3DLL4和Jagged2在银屑病患者皮损真皮中的表达水平与对照组相比,差异无统计学意义(P>0.05)。结论:Notch1-4,Jagged1、2,DLL1、3、4在银屑病患者皮损中表达增强,可能参与了银屑病的发病机制。
Objective： To explore the role of Notch family proteins in the pathogenesis of psoriasis. Methods： The patholog- ical specimens from 58 psoriatic patients and 28 individuals with epidermal nevus were collected. Immunohistochemical staining method was used to detect the localization and the expression of Notch signal receptors and ligands（Notch1-4, DLL1, 3, 4, and Jagged1, 2）. Results： ① Compared with the control group, the expression levels of epidermal notch（1, 2, 3, 4）, Jagged（1, 2） and DLL（1, 3, 4） in the psoriatic patients were significantly elevated（P〈0.05）. ② The expression levels of notch（1, 2, 3, 4）, Jagged1 and DLL（1, 3） were also significantly increased in the dermis of psoriatic patients in comparison with controls（P〈0.05）. ③ The differences of expression levels of dermal DLIA and Jagged2 were not significant between pso- riatic patients and control group（P〉0.05）. Conclusions： The expression levels of notch（1, 2, 3, 4）, Jagged（1, 2） and DLL （1, 3, 4） were enhanced in the lesions of psoriatic patients. Notch family proteins may be involved in the pathogenesis of psoriasis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2015年第3期135-139,共5页
Journal of Clinical Dermatology
基金
国家自然科学基金(81173270)资助项目
