摘要
目的探讨急性重症胰腺炎患者应用凝结芽孢杆菌的治疗效果,观察治疗前、后血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素(interleukin,IL)-1和IL-6水平变化。方法 68例急性重症胰腺炎患者按就诊时间分为2组,2008年10月—2011年4月就诊34例为对照组,2011年5月—2013年10月就诊34例为观察组,对照组给予禁食水、胃肠减压等常规治疗,观察组在常规治疗基础上给予凝结芽孢杆菌0.7g/次,3次/d,胃管内注入。治疗7d后评定2组疗效,记录2组治疗前、后血清TNF-α、IL-1和IL-6水平变化,并观察2组白细胞计数和血清淀粉酶恢复正常时间、腹痛腹胀缓解时间。结果观察组总有效率(94.12%)高于对照组(73.52%)(P<0.05);对照组治疗后TNF-α、IL-1和IL-6水平((22.80±6.05)、(21.98±5.37)、(32.87±6.80)μg/L)低于治疗前((59.65±13.18)、(58.13±6.75)、(79.03±9.11)μg/L)(P<0.05);观察组治疗后TNF-α、IL-1和IL-6水平((17.33±4.02)、(16.64±5.04)、(24.85±6.03)μg/L)低于治疗前((57.82±11.92)、(59.46±5.56)、(77.07±11.09)μg/L)(P<0.05),与对照组治疗后比较差异有统计学意义(P<0.05);观察组白细胞计数恢复正常时间、血清淀粉酶恢复正常时间、腹痛腹胀缓解时间((5.23±1.16)、(5.48±1.54)、(4.12±2.08)d)均短于对照组((7.94±2.15)、(8.37±2.12)、(7.40±2.06)d(P<0.05)。结论SAP患者应用凝结芽孢杆菌可使血清TNF-α、IL-1和IL-6水平下降,提高治疗有效率。
Objective To discuss the effect of Bacillus coagulans on severe acute pancreatitis and observe the changes of serum tumor necrosis factor-α（TNF-α）,interleukin（IL）-1and IL-6levels before and after treatment.Methods Sixtyeight patients with severe acute pancreatitis were divided into control group（from October,2008 to April,2011）and observation group（from May,2011 to October,2013）according to the visiting time,with 34 patients in each group.Control group received conventional treatment as absolute diet and gastrointestinal decompression,and observation group was injected via stomach tube Bacillus coagulans（0.7g per time,three times a day）besides the conventional therapy.The therapeutic effect was evaluated in two groups after 7-day treatment.The changes of serum TNF-α,IL-1,IL-6,the time of white blood cell count and serum amylase level returning to normal,and time of abdominal pain relieving were recorded and compared between two groups before and after treatment.Results The total effective rate was significantly higher in observation group（94.12%）than that in control group（73.52%）（P〈0.05）.The TNF-α,IL-1and IL-6levels were（22.80±6.05）,（32.87±5.37）and（32.87±6.80）μg/L in control group,and（17.33±4.02）,（16.64±5.04）and（24.85±6.03）μg/L in observation group after treatment,significantly lower than those before treatment in control group（（59.65±13.18）,（58.13±6.75）,（79.03±9.11）μg/L）and in observation group（（57.82±11.92）,（59.46±5.56）,（77.07±11.09）μg/L）（P〈0.05）,showing significantly differences between two groups after treatment（P〈0.05）.The time of white blood cell count and serum amylase level returning to normal,and time of abdominal pain relieving were shorter in observation group（（5.23±1.16）,（5.48±1.54）,（4.12±2.08）days）than those in control group（（7.94 ±2.15）,（8.37±2.12）,（7.40±2.06）days）（P〈0.05）.Conclusion Application of Bacillus coagulans could lower the levels of serum TNF-α,IL-1and IL-6,and improve the effective rate in patients with severe acute pancreatitis.
出处
《中华实用诊断与治疗杂志》
2015年第2期201-203,共3页
Journal of Chinese Practical Diagnosis and Therapy
