摘要
目的比较蠲饮泄肺方和清热化痰方分别联合西药治疗慢性阻塞性肺疾病急性加重期(AECOPD)痰热壅肺证的临床疗效。方法 60例AECOPD患者随机分为治疗组31例和对照组29例,所有患者均给予常规西药治疗的基础上,治疗组和对照组分别加服蠲饮泄肺方和清热化痰方,每日1剂,共7天。治疗前后对患者中医证候积分、呼吸困难评分(MMRC)、辅助呼吸肌动用评分进行评估,记录两组住院天数,并检测两组治疗前后血清C-反应蛋白(CRP)、降钙素原(PCT)水平。结果治疗组临床疗效总有效率为96.43%,对照组总有效率为96.29%,两组比较差异无统计学意义(P>0.05)。与对照组比较,治疗组治疗后喘息中医症状评分显著降低、MMRC评分显著改善(P<0.05);治疗组住院天数明显缩短(P<0.05)。治疗组与对照组中医证候总积分、辅助呼吸肌动用评分及血CRP、PCT水平组间比较差异无统计学意义(P>0.05)。结论与清热化痰方相比,蠲饮泄肺方能够取得相同的临床疗效,并且蠲饮泄肺方联合西药能更好地缓解AECOPD患者喘息症状、改善呼吸困难,缩短住院天数,有助于细菌感染控制。
Objective To compare the clinical efficacy of Juanyin Xiefei Formula （JYXFF） and Qingre Huatan Formula （QRHTF） combined with western medicine separately in treating acute exacerbation of chronic obstructive pulmonary disease （AECOPD） with phlegm and heat obstructing lung syndrome. Methods Totally 60 cases of AECOPD were randomly divided into treatment group of 31 cases and control group of 29 cases. All patients were routinely given western medicine treatment. The treatment group and the control group were given additional JYXFF and QRHTF respectively, one dose per day, for seven days. TCM syndrome score, dyspnea score （MMRC）, scores of the activity of accessory respiratory muscles were assessed before and after treatment. The number of days in hospi- tal were recorded and serum levels of C-reactive protein （CRP） and procalcitonin （PCT） were detected beibre and after treatment. Results The total effective rates in the treatment group and the control group were 96.43% and 96. 29% respectively, with no significant difference （P 〉 0. 05 ）. Compared with the control group, the scores of asthma the treatment group were significantly lower, with the MMRC scores improved significantly after treatments （P 〈 0. 05 ） and the hospitalization days shortened （P 〈 0.05 ）. As for the total scores of TCM syndromes and the activity of accessory respiratory muscles and serum CRP, PCT levels in the treatment group and control group showed no significant difference （P 〉 0. 05）. Conclusion JYXFF could achieve the same clinical efficacy as QRHTF and when combined with western medicine, it could release the asthmatic symptoms, difficulty in breathing, shorten hospitalization days and help control bacterial infection.
出处
《中医杂志》
CSCD
北大核心
2015年第5期387-391,共5页
Journal of Traditional Chinese Medicine
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目
关键词
慢性阻塞性肺疾病
急性加重
蠲饮泄肺方
清热化痰方
chronic obstructive pulmonary disease
acute exacerbati.on
Juanyin Xiefei Formula
Qingre HuatanFormula
