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肝再生磷酸酶-3和E-钙黏蛋白参与胃癌淋巴结转移过程 被引量：5

Involvement of phosphatase of regenerating liver-3 and E-cadherin in the process of the lymph node metastasis of gastric cancer
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摘要 目的 探讨肝再生磷酸酶-3（PRL-3）和E-钙黏蛋白（E-cadherin）与胃癌淋巴结转移状态、患者生存预后的关系.方法 应用免疫组织化学技术[链霉菌抗生物素蛋白-过氧化物酶（SP）法]检测53例胃癌组织和30例胃正常组织中PRL-3和E-cadherin的表达,分析两者与临床病理特征的关系.结果 PRL-3在正常胃黏膜组织中没有表达,在胃癌组织中PRL-3的阳性表达率为45.3％（24/53）.E-cadherin存在于大多数腺细胞的胞质膜,在胃癌组织中E-cadherin的阳性表达率为54.7％（29/53）.PRL-3的表达与淋巴结转移（P＜0.01）、Goseki分级（P＜0.01）、Borrmann分类（P＜0.01）和幽门螺旋杆菌感染（P＜0.05）明显相关.E-cadherin的表达与淋巴结转移（P＜0.01）、Borrmann分类（P＜0.01）和幽门螺旋杆菌感染（P＜0.01）明显相关.Lauren＆#39;s分型、PRL-3表达和E-cadherin表达是影响胃癌患者生存期的独立影响因素.结论 PRL-3和E-cadherin的表达均与淋巴结转移状态密切相关,并且两种蛋白均为影响胃癌患者生存期的独立影响因素. Objective To investigate the relationship between phosphatase of regenerating liver-3 （PRL-3） and E-cadherin with lymph node metastasis of gastric cancer,survival and prognosis.Methods The expression of PRL-3 and E-cadherin in 53 cases of gastric cancer tissues and 30 cases of normal gastric tissues was examined by immunohistochemical method.The relationship between PRL-3 and E-cadherin with the pathological parameters was statistically analyzed.Results PRL-3 was not expressed in normal gastric mucosa,and the positive expression of PRL-3 in gastric cancer tissues was 45.3% （24/53）.E-cadherin existed in most glandular cells of the cytoplasmic membrane,and the positive expression of E-cadherin in gastric cancer tissues was 54.7% （29/53）.The expression of PRL-3 was correlated with lymph node metastasis （P 〈 0.01）,Goseki grade （P 〈 0.01）,Borrmann classification （P 〈 0.01） and infection of Helicobacter pylori （P 〈 0.05）.The expression of E-cadherin was correlated with lymph node metastasis （P 〈 0.01）,Borrmann classification （P 〈 0.01） and infection of Helicobacter pylori （P 〈 0.01）.The expression of Lauren＆#39; s type,PRL-3 expression and E-cadherin were independent predictive factors of survival in patients with gastric cancer.Conclusion The expression of PRL-3 and E-cadherin was related with lymph node metastasis,and two proteins were the independent predictors of survival in gastric cancer patients.
作者 刘磊 韩亮
机构地区 华中科技大学同济医学院附属武汉中心医院胃肠外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2015年第2期313-315,共3页 Chinese Journal of Experimental Surgery
关键词 胃癌 肝再生磷酸酶-3 E-钙黏蛋白 淋巴结转移 Gastric cancer Phosphatase of regenerating liver- 3 E -cadherin Lymph node metastasis
分类号 R735.2 [医药卫生—肿瘤]
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参考文献7

二级参考文献34

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共引文献21

同被引文献36

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中华实验外科杂志
2015年 第2期

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