摘要
目的观察氨氯地平联合美托洛尔治疗轻中度高血压的疗效。方法将240例轻中度高血压患者随机分为三组,联合用药组(氨氯地平片联合美托洛尔)、氨氯地平组、美托洛尔组,各80例。治疗8周后比较三组间血压变化值、血压达标率及不良反应发生率差异。结果治疗8周后联合用药组血压变化率和血压达标率显著高于氨氯地平组和美托洛尔组,P<0.05;不良反应发生率(13.75%)则显著低于氨氯地平组(20.00%)和美托洛尔组(20.00%),P<0.05。结论相比于氨氯地平或美托洛尔单用,采用氨氯地平联合美托洛尔治疗轻中度高血压具有降压效果好、不良反应发生率低的优点。
Objective To investigate the clinical efficacy of amlodipine combined with metoprolol in the treatment of mild to moderate hypertension. Methods A total of 240 patients with mild to moderate hypertension were equally and randomly divided into three groups： combination group （treated with amlodipine combined with metoprolol）, amlodipine group （treated with amlodipine alone）, and metoprolol group （treated with metoprolol alone）. The rate of change in blood pressure, percentage of patients with normal blood pressure, and incidence of adverse events were compared between the three groups after 8 weeks of treatment. Results The combination group had significantly higher rate of change in blood pressure and percentage of patients with normal blood pressure than the amlodipine group and the metoprolol group （P〈0.05）. However, the combination group had a significantly lower incidence of adverse events than the amlodipine group and the metoprolol group （13.75% vs 20.00%and 20.00%, P〈0.05）. Conclusion Compared with amlodipine or metoprolol alone, amlodipine combined with metoprolol has better antihypertensive efficacy and causes fewer adverse events in the treatment of mild to moderate hypertension.
出处
《心血管病防治知识（学术版）》
2015年第2期17-19,共3页
Prevention and Treatment of Cardiovascular Disease
