摘要
目的了解并评价丙种球蛋白联合阿昔洛韦/更昔洛韦治疗小儿病毒性脑炎的临床应用价值。方法检索国内外数据库,收集丙种球蛋白联合阿昔洛韦/更昔洛韦治疗小儿病毒性脑炎的相关文献,并选取其中采用随机或半随机对照试验的文献,运用Review Manager 5.1软件进行分析。结果 1共纳入中文文献8篇,其中,C级文献3篇,B级文献5篇,共计患儿580例,其中试验组294例,对照组286例;2采用随机效应模型进行meta分析,结果显示采用丙种球蛋白联合阿昔洛韦/更昔洛韦治疗小儿病毒性脑炎,退热时间比单纯采用阿昔洛韦或更昔洛韦更短(Z=7.11,P<0.001),治疗无效率比单纯采用阿昔洛韦或更昔洛韦更低(Z=4.16,P<0.001),且不良反应较少;3漏斗图基本对称,提示所纳入的文献无发表偏倚。结论丙种球蛋白联合阿昔洛韦/更昔洛韦治疗小儿病毒性脑炎,有助于早日改善小儿临床症状,有效降低病毒性脑炎的病死率,临床使用安全,应用价值较高。
Objective To evaluate the clinical value of gamma globulin combined with acyclovir or ganciclovir for infant viral encephalitis. Methods We retrieved domestic and international databases, collected and selected related literatures with randomized or quasi randomized controlled trials, and then analyzed with Review Manager 5.1 software. Results Eight Chinese literatures（3 grade C and 5 grade B） contained 580 children（294 in the test group and 286 in the control group） in the analysis. Meta analysis with random effect model was used. The heat recovery time in the test group was shorter than that in the control group（Z = 7.11, P 〈0.001）, the ineffective rate in the test group was lower than that in the control group（Z = 4.16, P〈 0.001）, and the adverse reaction in the test group was scarce. Funnel plot was symmetric, indicating that the included 8 literatures had no publication bias. Conclusion Gamma globulin combined with acyclovir or ganciclovir can improve the clinical symptoms and reduce the mortality rate of infant viral encephalitis, which is safe and useful in clinical practice.
出处
《中南药学》
CAS
2015年第1期99-102,共4页
Central South Pharmacy
基金
湖南省科技厅项目(No.2011fj7014)
