摘要
目的探讨和分析下呼吸道感染患者的病原菌分布及其耐药性。方法回顾性分析2013年在金华市中心医院呼吸内科住院的下呼吸道感染患者合格痰标本细菌培养结果,然后进行细菌菌株的鉴定和药物敏感性检测。结果共分离出593株致病菌。其中,革兰阴性菌464株,占78.2%,前四位为:肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌、大肠埃希菌;革兰阳性菌49株(占8.3%),以金黄色葡萄球菌为主;真菌80株(占13.5%),以白假丝酵母菌为主。不论是革兰阴性杆菌还是革兰阳性球菌均普遍出现了多重耐药菌株。结论呼吸内科下呼吸道感染以革兰阴性菌为主,分离病原菌耐药现象普遍存在,临床应重视病原学检查。加强病原菌耐药性监测,合理使用抗菌药物。
Objective To investigate the distribution and drug resistance of pathogens causing lower respiratory tract infections. Methods A retrospective study was conducted to analyze the culture results and drug susceptibility of the bacterial strains from qualified sputum samples from hospitalized patients with lower respiratory tract infections in 2013 in the department of respiratory medicine in our hospital. Results In total 593 pathogens isolated,464 strains were gram-negative bacilli（78. 2%）,49 were gram-positive bacilli（8. 3%）,and 80 were fungi（13.5%）. Among gram-negative bacilli,the top four isolates were Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter baumannii and Escherichia coli. The most common gram-positive bacteria and fungi were Staphylococcus aureus and Candida albicans,respectively. Either Gram-negative or Gram-positive strains showed multidrug resistance. Conclusion Gram-negative bacilli are the most common pathogens causing lower respiratory tract infections. Multi-drug resistance is very common among the isolates in this study. Clinical physicians should pay more attention to the etiological examination,drug resistance monitoring and rational use of antimicrobial drugs.
出处
《中国微生态学杂志》
CAS
CSCD
2014年第8期900-902,913,共4页
Chinese Journal of Microecology
基金
教育部博士点博导基金(2012010111008)
卫生部国家临床重点专科建设项目
关键词
下呼吸道感染
病原菌
耐药性
Lower respiratory tract infections
Pathogen
Drug resistance
