摘要
目的:观察中医益肺健脾化瘀方治疗婴幼儿支气管哮喘的临床疗效,探讨尿乙酰氨基葡萄糖苷酶(NAG)、微量白蛋白(mALB)、转铁蛋白(TRF)等指标检测对婴幼儿支气管哮喘临床用药起指导作用。方法:选择符合纳入病例标准的支气管哮喘患儿100例,采用多中心、队列研究方案分为2组,对照组50例采用常规西医处理方法用药,治疗组50例在此基础上加活血化瘀、益气健脾药,观察2组患儿在哮喘的症状体征、控制病情、减少复发或减轻发作程度等方面的疗效。同时检测发作期、缓解期及中药防治半年后尿NAG、mALB、TRF变化,并与正常健康体检儿进行对照。结果:治疗组50例患儿中显效32例,有效16例,无效2例,总有效率96.0%;对照组50例患儿中显效18例,有效22例,无效10例,总有效率80.0%,2组临床疗效比较差异有统计学意义(P<0.05);治疗组患儿治疗3个疗程后咳嗽、痰鸣、喘息、肺部哮鸣音临床症状改善程度明显优于对照组,差异有统计学意义(P<0.05);发作期不同病情程度患儿的NAG明显高于正常组,且差异有统计学意义(P<0.05或<0.01);发作期病情中度、重度患儿的mALB均明显高于正常组,且差异有统计学意义(P<0.01);发作期病情重度患儿的TRF明显高于正常组,且差异有统计学意义(P<0.01);发作期重度病情程度患儿的NAG、mALB与中度比较差异有统计学意义(P<0.01);缓解期患儿NAG明显高于对照组,且差异有统计学意义(P<0.05);缓解期中药预防半年后尿NAG、mALB、TRF变化与正常组比较差异无统计学意义(P>0.05),说明本研究所用中药安全有效。结论:中医益肺健脾化瘀方治疗婴幼儿支气管哮喘临床疗效显著,发作期尿NAG、mALB、TRF指标对临床用药有较好的指导作用。
Objective： To observe the clinical curative effect of Yifei Jianpi Huayu Decoction in the treatment of infantile bronchial asthma; discussion urine N-Acetyl-D-Glucosaminidase （NAG）, albumin （mALB） , transferrin （TRF） were detected to guide clinical medication in bronchial asthma children play. Methods ：100 patients with bronchial asthma in children with the inclusion criteria, the scheme of multi-center, cohort study, and were divided into two groups, 50 cases in the control group using conventional western medicine treatment method of treatment, the treatment group of 50 cases on the basis of promoting blood circulation to remove blood stasis, replenishing Qi and spleen drugs, observation of two groups of children with disease control in the signs, symptoms of asthma to reduce the effect, recurrence or reduce the degree of attack etc. Simultaneous detection of exacerbation, alleviate the changes of urinary NAG, mALB, TRF and traditional Chinese medicine treatment for half a year, compared with normal healthy children. Results： The treatment group of 32 cases markedly effective in 50 cases, effective 16 cases, invalid 2 cases, the total efficiency was 96% , control group 50 cases in 18 cases, effective 22 cases, invalid 10 cases, the total efficiency of 80%, there was significant difference between the clinical curative effect of the two groups （P 〈 0.05 ） ; treatment group children after 3 course of treatment of cough, phlegm, wheezing, pulmonary wheezing symptoms improved significantly better than the control group, and the difference was statistically significant （ P 〈 0. 05 ） ; onset of different severity in children with NAG was significantly higher than that in normal group, and the difference was statistically significant （ P 〈 0.05 or P 〈 0.01 ） moderate, severe illness ; exacerbation in children with mALB were significantly higher than normal group, and the difference was statistically significant （ P 〈0. 01 ） ; onset of severe illness in children with TRF was significantly higher than the normal group, and the difference was statistically significant （P 〈 0.01 ） ; onset of disease in children with severe degree of NAG, mALB and moderate comparison the difference was statistically significant （ P 〈 0. 01 ） ; remission in children with NAG was significantly higher than the control group, and the difference was statistically significant （ P 〈 0. 05 ） ; traditional Chinese medicine prevention remission after the first half of NAG, mALB, urinary TRF and normal group were not president Ji Xueyi Yi （P 〉 0. 05） ; the traditional Chinese medicine which is safe and effective. Conclusion： The curative effect of traditional Chinese medicine Yifei Jianpi Huayu Decoction in the treatment of infantile bronchial asthma exacerbation significantly, urine NAG, mALB, TRF index is a better guide to clinical medication.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2014年第7期945-947,共3页
JOURNAL OF BASIC CHINESE MEDICINE
