摘要
目的：以24 h尿碘为参照,对学龄儿童晨尿碘浓度这一指标在碘缺乏病监测中的应用进行探讨,并与育龄妇女相应指标进行比较。方法：以同一地区8~10岁学龄儿童和育龄妇女为目标人群,尽量选择既有儿童又有育龄妇女的家庭户,同时收集两类人群晨尿和连续两天24 h尿,并分别测定其尿碘浓度。结果：儿童晨尿、第1天24 h尿、第2天24 h尿的碘浓度分别为（344±210）μg/L、（318±177）μg/L、（306±144）μg/L,妇女则为（366±232）μg/L、（321±151）μg/L、（366±160）μg/L。161例儿童与149例妇女连续两天24 h尿之间的碘浓度均呈正相关,差异有统计学意义（儿童：r=0.394,Pr〈0.001;妇女：r=0.380,Pr〈0.001）。不同人群晨尿和一天24 h尿的碘浓度均数均呈正相关,差异有统计学意义（儿童：r=0.297,Pr〈0.001;妇女：r=0.281,Pr〈0.001）。同一家庭户的学龄儿童和妇女之间的晨尿及24 h尿中碘浓度呈正相关,差异有统计学意义（晨尿：r=0.366,Pr〈0.001;24 h尿：r=0.360,Pr〈0.001）。结论：不同人群24 h尿中碘浓度平均水平在一段时期内较为稳定,晨尿的碘浓度能反映相应人群近期的碘水平,可用学龄儿童晨尿的碘浓度平均水平评价同地区不包括孕妇及哺乳妇女的育龄妇女的碘状态。
Objective： To explore the application of morning fasting urinary iodine concentration in iodine deficiency surveillance among school- aged children with 24- hour urinary iodine concentration as reference,compare with related indicators in women of childbearing age. Methods： The school- age children aged 8- 10 years old and the women of childbearing age were selected as study objects,the families with children and women of childbearing were selected preferentially; morning fasting urine and consecutive two- day 24- hour urine specimens were collected,urinary iodine concentrations were measured. Results： The mean iodine concentrations of morning fasting urine,the first 24- hour urine and the second 24- hour urine were（ 344 ± 210） μg / L,（ 318 ± 177） μg / L,（ 306 ± 144） μg / L in children and（ 366 ± 232） μg / L,（ 321 ± 151） μg / L,（ 366 ± 160） μg / L in women of childbearing age. There were positive correlations between the first 24- hour urinary iodine concentration and the second 24- hour urinary iodine concentration in children and women of childbearing age,respectively（ children： r = 0. 394,Pr 0. 001; women： r = 0. 380,Pr 0. 001）. There were positive correlations between morning fasting urinary iodine concentration and 24- hour urinary iodine concentration in children and women of childbearing age,respectively（ children：r = 0. 297,Pr 0. 001; women： r = 0. 281,Pr 0. 001）. In the same family,there were positive correlations in morning fasting urinary iodine concentration and 24- hour urinary iodine concentration between children and women of childbearing age,respectively（ morning fasting urine： r = 0. 366,Pr 0. 001; 24- hour urine： r = 0. 360,Pr 0. 001）. Conclusion： The mean 24- hour urinary iodine concentrations among children and women of childbearing age were relatively stable during a period of time. Morning urinary iodine concentration can reflect recent iodine level in population. Morning urinary iodine concentration among school- age children can evaluate iodine status of women of childbearing age in the same area except pregnant and lactating women.
出处
《中国妇幼保健》
CAS
2015年第8期1183-1186,共4页
Maternal and Child Health Care of China
基金
国家自然基金重点项目〔30230330〕
江苏省疾病预防控制中心重点人才基金〔JKRC2011016〕
江苏省血地寄防应用性科研课题〔X200721
X201120〕
关键词
儿童
尿碘
碘状态
Child
Urinary iodine
Iodine status
