摘要
目的 探讨血脂代谢与大肠癌的关系.方法 检测182例大肠癌和86例对照组患者TG、TC、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）,分别比较大肠癌和对照组不同部位、不同性别大肠癌患者血脂水平.结果 大肠癌组TC（5.51±0.76） mmol/L,明显高于对照组的（4.84±0.53） mmol/L（t =2.41,P＜0.05）;大肠癌组HDL-C（0.85±0.26） mmol/L,明显低于对照组的（1.24±0.27） mmol/L（t=-3.56,P ＜0.05）;大肠癌组TG（1.72±0.32） mmol/L、LDL-C（3.00±0.43） mmol/L与对照组的（1.61±0.26） mmol/L、（2.75±0.41） mmol/L比较差异均无统计学意义（t=0.89、1.45,均P＞0.05）.男性大肠癌组TC（5.96±0.87） mmol/L,明显高于女性大肠癌组的（5.26 ±0.74） mmol/L（t =2.10,P＜0.05）;左半结肠癌组TC（6.07±0.78） mmol/L,明显高于右半结肠癌组的（5.14 ±0.56） mmol/L（t =3.24,P＜0.05）;左半结肠癌组的HDL-C （0.75±0.26） mmol/L,明显低于右半结肠癌组的（1.07±0.19）mmol/L（t=-3.20,P＜0.05）.结论 TC与大肠癌呈正相关,而HDL-C与其呈负相关.
Objective To explore the relationship between dyslipidemia and colorectal cancer.Methods The levels of total cholesterol（TC）,triglyceride （TG）,1ow density lipoprotein-cholesterol （LDL-C） and high density lipoprotein-cholesterol （HDL-C） of 182 patients with colorectal cancer and 86 controls were tested.The serum lipids levels between the colorectal cancer group and control group,colorectal cancer with different location,different gender were compared.Results The level of TC in the colorectal cancer group [（5.51 ± 0.76） mmol/L] was significantly higher than that of the control group [（4.84 ± 0 53） mmol/L] （t =2.41,P 〈 0.05） ; The level of HDL-C in the colorectal cancer group[（0.85 ± 0.26） mmol/L] was significantly lower than that of the control group [（1.24 ± 0.27） mmol/L] （t =-3.56,P 〈 0.05）.There were no significant differences in the 1 evels of TG and LDL-C between the colorectal cancer group and control group（t=0.89,1.45,all P 〉 0.05）.TC level in the male colorectal cancer group [（5.96 ± 0.87） mmol/L] was significantly higher than that of the female colorectal cancer group [（5.26 ± 0.74） mmol/L] （t =2.10,P 〈 0.05）.The level of TC in the distal colon and rectal cancer group was （6.07 ± 0.78） mmol/L,which was significantly higher than （5.14 ± 0.56）mmol/L of the proximal colon cancer group （t =3.24,P 〈 0.05） ;The level of HDL-C in the distal colon and rectal cancer group was （0.75 ± 0.26） mmol/L,which was significantly lower than （1.07 ± 0.19） mmol/L of the proximal colon cancer group （t =-3.20,P 〈 0.05）.Conclusion TC was positively correlated with colorectal cancer,and HDL-C was negatively correlated with colorectal cancer.
出处
《中国基层医药》
CAS
2015年第3期354-356,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
广东省深圳市科技创新委员会基础研究项目（JCYJ20140414170821217）
关键词
大肠癌
总胆固醇
甘油三酯
低密度脂蛋白胆固醇
高密度脂蛋白胆固醇
Colorectal cancer
Total cholesterol
Triglyceride
Low density lipoprotein - cholesterol
Highdensity lipoprotein - cholesterol
