摘要
目的:探讨乌司他丁治疗创伤失血性休克的效果及对患者肝肾功能的影响。方法:110例创伤失血性休克患者随机分为对照组(n=55)和观察组(n=55)。对照组采用常规抗休克治疗,观察组在对照组基础上加用乌司他丁微量注射泵静注。两组疗程均为1周。观察两组患者术前和术后心率、尿量、肝功能、肾功能及炎性细胞因子水平变化。结果:观察组术后3 h、6 h心率明显低于治疗前,尿量明显多于治疗前;观察组术后第1、第3天的AST、ALT及LDH均明显低于同期对照组(P<0.05);观察组术后第1天BUN、SCr、β2-MG均明显高于术前(P<0.05),术后第3天BUN、SCr、β2-MG与对照组比较,差异有统计学意义(P<0.05);观察组术后第1天IL-1β水平较术前显著升高(P<0.05),术后第3天血浆IL-1β水平与术前比较,差异无统计学意义(P>0.05);观察组术后第1、第3天IL-6水平均较术前显著升高(P<0.05),且较对照组显著下降(P<0.05)。结论:乌司他丁对创伤失血性休克患者肝肾功能具有一定的保护作用,同时还可改善患者心率及尿量。
Objective：To investigate the effect of ulinastatin on liver and kidney function in the patients with traumatic hemorrhag-ic shock. Methods：Totally 110 patients with traumatic hemorrhagic shock were divided into the control group （n=55） and the obser-vation group （n=55） according to the random number table. The control group received the conventional anti-shock treatment, and the observation group received ulinastatin with intravenous injection by syringe pump additonally. The changes of heart rate, urine vol-ume, liver function, renal function and inflammatory cytokine levels in the two groups were observed before and after the operation. Results：The heart rate at the 3rd h and 6th h after the operation in the observation group was significantly lower than that before the treatment , and urine volume was aslo significantly more than that before the treatment. The postoperative AST, ALT and LDH at the 3rd h and 6th h in the observation group were significantly lower than those in the control group at the same period, and the difference was significant （P〈0. 05）. The postoperative BUN, SCr andβ2-MG on the 1st day in the observation group were significantly higher than those before the surgery, and the difference was significant （P〈0. 05）;the postoperative BUN, SCr andβ2-MG on the 3rd day in the observation group were significantly different from those in the control group （P〈0. 05）. The postoperative IL-1β level on the 1st day in the observation group was significantly higher than that before the surgery （P〈0. 05）;the serum IL-1βlevel on the 3rd day in the observation group showed no statistically significant difference from that before the surgery （P〉0. 05）;the IL-6 levels on the 1st and 3rd day in the observation group were significantly higher than those before the surgery, however, lower than those in the control group with significant differences （P〈0. 05）. Conclusion： Ulinastatin has protective effect on liver and kidney function in the pa-tients with traumatic hemorrhagic shock, and can improve heart rate and urine output of the patients.
出处
《中国药师》
CAS
2015年第3期424-426,共3页
China Pharmacist
关键词
创伤
失血性休克
乌司他丁
肝肾功能
Trauma
Hemorrhagic shock
Ulinastatin
Liver and kidney function
