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ABCA1介导胆固醇外流及抗炎的信号通路研究进展 被引量：7

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摘要 ABCA1抗动脉粥样硬化的作用主要通过以下两种途径:介导细胞内胆固醇流出和抑制炎症。载脂蛋白与ABCA1的相互作用可激活多个信号通路,包括JAK2/STAT3、蛋白激酶A(PKA)、Rho家族G蛋白CDC42和蛋白激酶C(PKC)等信号通路。ABCA1通过修饰细胞膜脂筏或直接激活信号通路而介导脂质流出和发挥抗炎功能。对这些信号通路的认识,能为动脉粥样硬化相关疾病提供新的治疗靶点。
作者 谭玉林 唐艳艳 张敏 唐朝克
机构地区 南华大学心血管疾病研究所 湘南学院病理研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2015年第1期52-56,共5页 Progress in Physiological Sciences
基金 国家自然科学基金(81170278 81370377) 湖南省自然科学基金项目面上项目(2015JJ2131) 湖南省卫生厅医药卫生科研计划课题项目(B2014-070)资助课题
关键词 三磷酸腺苷结合盒转运体A1(ABCA1) 信号转导通路 胆固醇流出 抗炎
分类号 R363 [医药卫生—病理学]
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参考文献14

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二级参考文献29

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共引文献10

同被引文献76

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生理科学进展
2015年 第1期

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