摘要
在山西省煤炭中心医院妇产科采集产前检查孕妇血清标本,采用酶联免疫吸附试验(ELISA)检测血清弓形虫IgG抗体。共调查466名孕妇,血清弓形虫IgG抗体阳性率为5.58%(26/466);不同年龄和职业孕妇弓形虫抗体阳性差异无统计学意义(χ2年龄=0.097,χ2职业=6.309,P>0.05);随文化程度的增高,弓形虫抗体阳性率逐渐降低(χ2=10.964,P<0.01);有动物接触史的孕妇弓形虫IgG抗体阳性率25.93%,无接触史的孕妇弓形虫IgG抗体阳性率为4.33%,差异有统计学意义(χ2=22.522,P<0.01);有不良孕产史的孕妇弓形虫IgG抗体阳性率为28.57%,无不良孕产史孕妇阳性率为4.11%,差异有统计学意义(Fisher's Exact Test,P<0.01)。太原市孕妇弓形虫感染率较高,喂养宠物是弓形虫感染的重要因素。同时,弓形虫感染也是导致不良孕产结局的重要原因。应采取健康教育、早期检查及治疗等综合性预防控制弓形虫感染措施,提高生育质量。
Objective To ascertain the prevalence of Toxoplasma gondii infection in pregnant women in order to formulate scientific strategies for prevention of congenital toxoplasmosis. Methods Serum specimens were collected and demographic information,including age,educational level,occupation,and history of obstetric abnormalities was obtained from pregnant women seen at Shanxi Coal Center Hospital.An enzyme-linked immunosorbent assay（ELISA）was used to detect serum anti-T.gondii IgG antibodies. Results Subjects were 466 pregnant women in total.Women tested positive for anti-T.gondii IgG antibodies at a rate of 5.58%（26/466women）.However,there were no significant differences in the rate at which women tested positive for those antibodies in terms of age and occupation（ageχ2=0.097,occupation：χ2=6.309,P〉0.05）.As the level of education increased for pregnant women,the rate at which they tested positive for anti-T.gondii IgG antibodies gradually decreased（trendχ2=10.964,P=0.004）.Pregnant women with a history of contact with animals tested positive for antibodies at a significantly higher rate than those with no such history（χ2=22.522,P=0.000）.Pregnant women with a history of obstetric abnormalities tested positive for antibodies at a significantly higher rate than those with normal pregnancies（Fisher＇s Exact Test,P=0.000）. Conclusion Pregnant women in Taiyuan tested positive for anti-T.gondii IgG antibodies at a higher rate than the general population.Pets were an important factor for T.gondii infection,and T.gondii infection was a key reason for adverse pregnancy outcomes.Health education,early detection,and comprehensive treatment should be used to improve reproductive quality.
出处
《中国病原生物学杂志》
CSCD
北大核心
2015年第1期I0004-I0004,F0003,共2页
Journal of Pathogen Biology
关键词
弓形虫
孕妇
IGG抗体
Toxoplasma gondii
pregnant women
ant-T, gondii IgG antibodies
