摘要
目的:探讨金荞麦及其有效成分治疗肠易激综合征(Irritable Bowel Syndrome,IBS)的可能机制。方法:非相关文献知识工具ARROWSMITH软件。结果:金荞麦及其有效成分在分子或细胞水平对Toll样受体(toll-like receptor,TLR)、肿瘤坏死因子α(TNFα)、血管内皮生长因子(VEGF)、环氧合酶(COX-2)相关因子具有调节作用,而上述指标的不同表达同时也是造成IBS的重要相关因素。结论:金荞麦及其有效成分可能通过下调病变肠道细胞TLR4、降低TNFα的分泌和释放、降低IBS患者异常高表达的VEGF、降低IBS患者肠道组织COX-2的表达等环节发挥治疗IBS的作用,基于非相关文献知识发现法能为实验室的验证性研究提供参考。
Objective： To study the possible mechanism of fagopyrum cumosum and its effective components in the treatment of irritable bowel syn- drome. Method Software of ARROWSMITH based on theory of Swan＇s noninterative literature-bases knowledge discovery. Result： Fagopyrum cumosum and its effective components regulated the expression of toll-like receptor, TNFa, VEGF, COX-2 in the cellular and molecular level, and the abnormal expression of the aboved factors also participated in irritable bowel syndrome. Conclusion： The software of Arrowsmith could provide the prospects for the regulatory role of Fagopyrum cumosum and its effective components used for the research of irritable bowel syndrome.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2014年第6期190-193,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目资助(81173174
81202655)
科技部十一五科技支撑计划(2008BAI51B02)
关键词
金荞麦
有效成分
肠易激综合征
非相关文献知识
Arrowsmith
Fagopyrum cumosum
effective components
Irritable Bowel Syndrome
noninterative literature-bases knowledge discovery
arrowsmith
