摘要
目的探讨血清胃泌素17(G17)水平与胃癌及癌前疾病的相关性。方法纳入2011年-2012年于中国医科大学附属第一医院消化内科就诊患者1 336例,应用酶联免疫吸附测定法(ELISA)检测血清G17水平及幽门螺杆菌Ig G(H.pylori-Ig G)抗体滴度。结果在60岁以上、H.pylori-Ig G阴性、萎缩性胃炎(AG)组及胃癌(GC)组中,女性患者血清G17水平均显著高于男性患者(P<0.05)。在非AG组及异型增生(GD)组中,H.pylori阳性患者血清G17水平显著高于H.pylori阴性患者(P<0.05)。在所有患者中,与SG组相比,GC、胃黏膜糜烂(GE)和胃溃疡(GU)组血清G17水平显著升高(P<0.05);与浅表性胃炎伴糜烂(SG-IM)组相比,GD、GC、GE和GU组G17水平显著升高(P<0.05);与AG组相比,GC、GE和GU组G17水平显著升高(P<0.05)。在H.pylori阴性患者中,与SG组相比,GC组和GU组血清G17水平显著升高(P<0.05);与SG-IM组相比,AG、GC、GE和GU组G17水平显著升高(P<0.05);与GD组相比,GU组血清G17水平显著升高(P=0.007)。结论血清G17水平受患者性别及H.pylori感染等相关因素的影响,在从SG、SG-IM、AG、GD到GC的动态变化过程中呈逐渐升高的趋势,且GC患者较其他疾病明显升高。血清G17可能作为胃癌的生物标志物,有望成为胃癌筛查及早期诊断的一个重要观测指标。
Objective To investigate the association between serum G17 levels and precancerous lesions and gastric cancer. Methods From 2011 to 2012,a total of 1 336 participants were selected and enrolled in this study. G17 and H. pylori-Ig G were measured with ELISA. Results The level of serum G17 in females was significantly higher than that in males in those ≥60 years,a negative status of H. pylori-Ig G,and in atrophic gastritis（ AG） and gastric cancer（ GC）individuals（ P 〈0. 05）. The level of serum G17 was higher in H. pylori seropositive individuals than in H. pylori-seronegative individuals with non-AG and gastric dysplasia（ GD）（ P〈0. 05）. In total samples,G17 was significantly higher in GC,gastric erosion（ GE） and gastric ulcer（ GU） groups than that in SG group（ P 〈0. 05）; compared with SGIM group,G17 was significantly higher in GD,GC,GE and GU groups（ P 〈0. 05）; G17 were significantly higher in GC,GE and GU groups than that in AG group（ P 〈0. 05）. In H. pylori seronegative individuals,the serum G17 were significantly higher in GC and GU than that in superficial gastritis（ SG）（ P 〈0. 05）; Compared with SG-GIM,the serum G17 were significantly higher in AG,GC,GE and GU groups（ P 〈0. 05）; Compared with GD,the serum G17 was higher in GU group（ P = 0. 007）. Conclusion The levels of serum G17 is influenced by the gender and the status of H. pylori infection,which is gradually raised in the gastric disease progression from SG,SG-IM,AG,GD to GC,especially for the patients with GC. As a biomarker of gastric cancer,it is expected to be an important indicator in screening of disease and early diagnosis.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第2期161-165,共5页
Chinese Journal of Gastroenterology and Hepatology
关键词
胃泌素
萎缩性胃炎
胃癌
幽门螺杆菌
Gastrin
Atrophic gastritis
Gastric cancer
Helicobacter pylori
