摘要
目的探讨直肠小细胞癌Cox-2、nm23和MMP-3的表达及与临床病理特征的关系。方法应用免疫组织化学方法及组织芯片技术,观察63例直肠小细胞癌Cox-2、nm23和MMP-3的表达情况。结果 Cox-2、MMP-3阳性表达率与直肠小细胞癌的浸润深度、肠系膜淋巴结转移有关,随浸润深度加深,淋巴结转移率增加而升高(P<0.05)。Cox-2、MMP-3阳性表达率与直肠小细胞癌的TNM分期无关(P>0.05),nm23蛋白的阳性表达与肠系膜淋巴结转移,TNM分期有关,随淋巴结转移,TNM分期的增加而减低(P<0.05),与浸润深度无关(P>0.05)。Cox-2、nm23和MMP-3的表达与患者年龄、性别无关(P>0.05)。结论直肠小细胞癌的nm23、Cox-2和MMP-3的表达与临床预后密切相关,联合检测可预测直肠小细胞癌的恶性程度及判断预后。
Objective To investigate the correlation between expression of Cox-2,nm23 and MMP-3 in small cell carcinoma of the rectum and clinicopathological characteristics .Methods The expression levels of Cox-2,nm23,MMP-3 in 63 cases of small cell carcinoma of rectum were detected by immunohistochemistry and tissue microarray technology .Results The positive expression rates of Cox-2,and MMP-3 were correlated to mesenteric lymph node metastasis and depth of tumor invasion,with the increase of infiltration depth of tumor ,lymph node metastasis rate was increased （ P 〈0.05）.The positive expression rates of Cox-2 and MMP-3 were not correlated to TNM staging （ P 〉0.05）.However positive expression of nm23 protein was related with mesenteric lymph node metastasis and TNM staging （ P 〈0.05）,with lymph node metastasis and increase of TNM stage,which was decreased （ P 〈0.05）,however,which was not related to infiltration depth of tumor （ P〉0.05）.The expression levels of Cox-2,nm23,MMP-3 were not correlated to patient＆#39;s age and sex （ P 〉0.05）.Conclusion The expression levels of Nm23,Cox-2 and MMP-3 in small cell carcinoma of rectum are closely related to clinical prognosis , and combined detection can predict the malignant degree of tumor and can evaluate patient ’ s prognosis .
出处
《河北医药》
CAS
2015年第4期497-500,共4页
Hebei Medical Journal
关键词
环氧合酶
基质金属蛋白酶
组织芯片
免疫组化
直肠小细胞癌
cyclooxygenase
matrix metalloproteinases
tissue microarray technology
immunohistochemistry
samall cell carcinoma of the rectum
