摘要
目的比较丹参多酚酸盐与辛伐他汀治疗老年不稳定心绞痛的临床疗效。方法收集135例确诊为老年不稳定心绞痛患者,随机分为辛伐他汀治疗组66例与丹参多酚酸盐治疗组69例,两组患者在常规治疗的基础上分别采用辛伐他汀与丹参多酚酸盐治疗;另外选取30名健康人作为正常对照组。根据患者治疗前后心绞痛疗效、心电图改善情况判断两组患者治疗后的总有效率,分析正常组及两个治疗组患者治疗前后血液中的一氧化氮(NO)、血浆内皮素(ET)、白细胞介素-6(IL-6)以及肿瘤坏死因子-α(TNF-α)4个指标的变化情况,并观察药物是否存在不良反应。结果辛伐他汀治疗组与丹参多酚酸盐治疗组经4个疗程治疗后总有效率分别为75.8%和89.2%;与辛伐他汀治疗组相比,丹参多酚酸盐治疗组经治疗后患者NO含量显著上升(P<0.05),ET含量显著下降(P<0.05),IL-6及TNF-α因子水平均显著降低(均P<0.05)。两组患者治疗期间均未出现不良反应。结论在常规治疗的基础上,采用丹参多酚酸盐辅助治疗老年不稳定心绞痛的效果优于辛伐他汀。
Objective To compare the clinical curative effect of elderly unstable angina pectoris treated by salvia miltiorrhiza polyphenols acid salt and simvastatin.Methods 135 elderly patients with unstable angina pectoris were randomly divided into simvastatin treatment group（66 cases）and salvia miltiorrhiza polyphenols acid salt treatment group（69 cases）.Two groups of patients were treated with simvastatin or salvia miltiorrhiza polyphenols acid salt on the basis of conventional treatment.Then 30 cases of healthy people was chose as the normal control group.The total effective rates of two groups of patients after treatment were judged according to the curative effect before and after treatment in patients with angina pectoris and electrocardiogram.a total of four changes of the indicators including nitric oxide（NO）in the blood,plasma endothelin（ET）,interleukin 6（IL-6）and tumor necrosis factor alpha（TNF alpha）of patients in the normal group and the two treatment groups after treatment were observed,and adverse drug reactions were observe.Results The total effective rate of patients of simvastatin treatment group and salvia miltiorrhiza polyphenols acid salt treatment group were 75.8% and 89.2%,respectively（P〈0.05）.Compared with simvastatin treatment group,NO after treatment in patients of salvia miltiorrhiza polyphenols acid salt treatment group increased significantly（P〈0.05）,ET decreased significantly（P〈0.05）,IL-6factors reduced significantly（P〈0.05）and TNF-αsignificantly reduced（P〈0.05）.During treatment,two groups of patients all had no adverse reaction.Conclusion On the basis of conventional treatment,auxiliary treatment effect of salvia miltiorrhiza polyphenols acid salt on elderly unstable angina is better than simvastatin.
出处
《西部医学》
2015年第3期352-355,共4页
Medical Journal of West China
基金
国家自然科学基金(81100071)
