摘要
目的探讨厄贝沙坦对原发性高血压患者的治疗效果及血清炎症因子水平的影响。方法选择2012年12月至2014年2月我院收治的原发性高血压患者73例,按随机数字表法分为观察组(接受厄贝沙坦治疗)39例和对照组(接受硝苯地平治疗)34例,治疗12周后比较2组患者临床疗效;并于治疗前后检测肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs CRP)、白细胞介素6(IL-6)、IL-8水平。结果 2组患者治疗后血压、心率、TNF-α、hs CRP、IL-6、IL-8水平显著降低,与治疗前相比差异具有统计学意义(P<0.05);治疗后2组间比较,观察组炎性指标均低于对照组,差异亦有统计学意义(P<0.05)。观察组治疗4周后,尿素氮、胆固醇、肌酐、三酰甘油及丙氨酸氨基转移酶与治疗前相比较,差异无统计学意义(P>0.05);血糖治疗4周后水平明显低于治疗前,差异有统计学意义(P<0.05)。结论厄贝沙坦能够有效降低原发性高血压患者TNF-α、hs CRP、IL-6、IL-8水平,控制血压和心率,减少心血管不良事件的风险。
Objective To explore the clinical effect of irbesartan in treatment for essential hypertension and to investigate the serum levels of inflammatory cytokines. Methods Seventy-three cases of essential hypertension treated in our hospital from December 2012 to February 2014 were randomly divided into the observation group（ 39 cases） and control group（ 34 cases）. After 12 weeks of treatment,the clinical effects of two groups were analyzed and compared; and the levels of tumor necrosis factor alpha（ TNF-α）,high sensitive C reactive protein（ hs CRP）,interleukin 6（ IL-6）,interleukin 8（ IL-8） before and after the treatment were detected. Results After treatment,heart rate,blood pressure,levels of TNF-α,hs CRP,IL-6,IL-8 were significantly decreased in two groups（ P〈0. 05）,especially in the observation group（ P〈0. 05）. After 4 weeks＇ treatment,the levels of blood urea nitrogen,creatinine,alanine aminotransferase,cholesterol,physiological index showed no significant changes（ P〉0. 05）; the blood glucose was significantly lower than that before treatment in the observation group（ P〈0. 05）. Conclusions Irbesartan can effectively reduce the levels of TNF-α,hs CRP,IL-6,IL-8 in the patients with essential hypertension,and can control blood pressure and heart rate,reduce the risk of adverse events.
出处
《实用老年医学》
CAS
2015年第2期125-127,共3页
Practical Geriatrics
基金
湖北省十堰市科技局项目(2011063)
关键词
厄贝沙坦
原发性高血压
临床疗效
炎症因子
irbesartan
essential hypertension
clinical efficacy
inflammatory cytokines
