摘要
目的：探讨冠心病患者心外膜脂肪脂联素水平与冠状动脉病变程度的关系。方法选择冠心病及心脏瓣膜病手术患者168例，分为冠心病组86例和瓣膜病组82例，同时冠心病组按冠状动脉病变程度积分分为＜30分23例、30～90分35例、＞90分28例，分别采集患者的心外膜脂肪及血清标本，采用酶联免疫法及RT‐PCR分别测定血清脂联素及脂肪脂联素mRNA的表达。结果冠心病组血清脂联素低于瓣膜病组[（9．1±3．1）mg／L vs （13．5 ± 3．9）mg／L ，P＜0．05]，冠心病组积分＜30分、30～90分、＞90分患者血清脂联素分别为（12．3±4．8）mg／L、（9．1±4.5）mg／L和（7．2±5．1）mg／L ，差异有统计学意义（P＜0．05）。与瓣膜病组比较，冠心病组心外膜脂肪脂联素mRNA表达降低（P＜0．05）。结论老年冠心病患者随冠状动脉病变程度加重，血清及心外膜脂肪脂联素水平下降。
Obejective To study the relation between epicardial adiponectin level and coronary ar‐tery lesion in CHD patients .Methods One hundred and sixty eight CHD and valvular disease （VD） patients admitted to our hospital were divided into CHD group （n=86） and VD group（n=82） .Patients in CHD group were further divided into 〈30 lesion score group （n=23） ,30-90 le‐sion score group （n=35）and 90 lesion score group （n=28） .Epicardial adipose tissue and serum samples were taken from the patients .Their serum adiponectin level was measured and adipokine mRNA expression was detected by ELISA and RT‐PCR ,respectively .Results The serum adi‐ponectin level was significantly lower in CHD group than in VD group （9 .1 ± 3 .1 mg/L vs 13 .5 ± 3 .9 mg/L ,P〈0 .05） ,〈30 lesion score group ,30 -90 lesion score group and ＆gt;90 lesion score group （12 .3 ± 4 .8mg/L ,9 .1 ± 4 .5 mg/L ,7 .2 ± 5 .1 mg/L ,P〈 0 .05） .The adiponectin mRNA expression level was significantly lower in CHD group than in VD group （P〈0 .05） .Conclusion The serum epicardial adiponectin level decreases with the severity of coronary lesions in elderly CHD patients .
出处
《中华老年心脑血管病杂志》
CAS
2015年第3期270-272,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
河南省教育厅自然科学基金(2011A320009)
关键词
脂联素
冠心病
心包
心脏瓣膜疾病
RNA
信使
adiponectin
coronary disease
pericardium
heart valve diseases
RNA,messenger
