摘要
目的:探讨绝经妇女牙周炎患者龈沟液中骨保护素(OPG)和核因子-кB受体活化子配体(RANKL)的含量变化及意义。方法:采用吸潮纸尖法收集龈沟液(GCF)。酶联免疫吸附测定法(enzymelinked inmunosorbent assay,ELISA)测定龈沟液中的OPG、RANKL水平。结果:健康组和牙周炎组的GI、PLI、PD、AL比较,差异有统计学意义(P<0.01);两组的龈沟液中RANKL、OPG及RANKL/OPG比值比较,差异存在统计学意义(P<0.01)。结论:绝经妇女龈沟液中RANKL增加、OPG减少与牙周炎的发生、发展有密切关系。
Objective： To investigate the changes and significance of the receptor activator for osteoprotegerin （OPG） and receptor activator of nuclear factor kappa B ligand （RANKL） in gingival crevicular fluid （GCF） in postmenopausal women with periodontitis.Method： To follow careful sampling of GCF with moisture absorption paper point strips in patients. The level of OPG and RANKL was detected using ELISA technique.Result： The GI, PLI, PD, AL difference was significant between the two groups （P〈0.01）. There was significant difference in levels of RANKL, OPG and the ratio of RANKL/OPG in GCF between the two groups （P〈0.01）.Conclusion： The result suggests that the increasing production of RANKL and reducing production of OPG maybe associated with the initiation and progress of periodontitis.
出处
《中国医学创新》
CAS
2015年第7期42-44,共3页
Medical Innovation of China
关键词
龈沟液
OPG
RANKL
绝经妇女
牙周炎
OPG
RANKL
Gingival crevicular fluid
OPG
RANKL
Postmenopausal women
Periodontitis
