摘要
目的评估在妊娠期糖尿病(GDM)高危人群中,亚临床甲减(SCH)和甲状腺过氧化物酶抗体(TPO-Ab)与GDM是否具有关联性。方法纳入对象空腹血糖水平均≥4.4 mmol/L,检测其妊娠早期血清样本促甲状腺激素(TSH)、游离甲状腺素(FT4)、TPO-Ab、空腹及1h、2h血糖水平。Pearson's x^2检验和Student t/ANOVA检验分别用来进行计数资料和计量资料的比较,二元Logistic回归用于评估SCH和TPO-Ab与GDM的关系。结果 TSH水平升高,TPO-Ab(-)(OR=1.166,95%CI:0.666~2.043)或TSH水平正常,TPO-Ab(+)(OR=0.617,95%CI:0.344~1.108)并不增加GDM的发生风险;同样,TSH水平升高且TPO-Ab(+)(OR=2.030,95%CI:0.825~4.995)也未增加GDM的发生风险。结论在GDM高危人群中,妊娠早期SCH和/或TPO-Ab(+)并未增加GDM的发生风险。
Objective To estimate if there is relationship between subclinical hypothyroidism （SCH） or thyroid peroxidase antibody （ TPO- Ab） positivity and gestational diabetes mellitus （GDM） in pregnant women at high risk of diabetes. Methods Maternal serum samples in the first trimester of pregnancy were tested for thyroid-stimulating hormone （TSH）, free thyroxine （FT4）, TPO-Ab, fasting, 1 h and 2h glucose from women whose fasting plasma glucose ≥4.4 mmol/L. Pearson＇s χ^2 test and Student t/ANOVA test were performed to estimate univariate associations of categorical variables and continuous ones, respectively. Binary logistic regression analysis was also incorporated to assess the relationship among SCH, TPO-Ab and GDM. Results Neither the solitary elevation of TSH in TPO-Ab （ - ） subjects （ OR = 1. 166, 95% CI： 0. 666 - 2. 043） or TPO-Ab （ ＋ ） in euthyroid women （ OR = 0. 617,95% CI：0. 344 - 1. 108） nor a combination of elevated TSH and TPO-Ab （ ＋ ） （ OR = 2. 030,95% CI： 0. 825 - 4. 995） was associated with an increased risk of GDM during early pregnancy after adjustment for confounders. Conclusion SCH and/or TPO-Ab positivity in early pregnancy may not detrimentally affect gestational diabetes in pregnant women at high risk of GDM.
出处
《中国妇幼健康研究》
2015年第1期35-37,共3页
Chinese Journal of Woman and Child Health Research
基金
上海市科委医学引导类资助项目(No.134119a1100)
关键词
亚临床甲减
甲状腺过氧化物酶抗体
妊娠期糖尿病
关联性
subclinical hypothyroidism （ SCH ）
thyroid peroxidase antibody （ TPO-Ab ）
gestational diabetes mellitus （ GDM ）
correlation
