摘要
目的探讨C-反应蛋白(CRP)评估手足口病(HFMD)患儿病情及预后的作用。方法选取绍兴市上虞人民医院儿科诊治的HFMD患儿100例,按病情的严重程度分为普通型64例,重症型36例,检测CRP与白细胞(WBC)计数。结果①100例HFMD患儿CRP检查阳性率为95%(95/100),WBC计数检查阳性率为82%(82/100),两种检查方法阳性率比较差异有统计学意义(x^2=7.258,P<0.05);②重症型HFMD患儿治疗前CRP阳性率为100%(36/36),高于普通型患儿的92.19%(59/64),差异有统计学意义(x^2=6.175,P<0.05),重症型与普通型患儿WBC阳性率比较差异无统计学意义(x^2=1.224,P>0.05);③治疗前、后重症型HFMD患儿CRP水平、WBC计数均高于普通型,差异有统计学意义(治疗前t_(CRP)=8.452、t_(WBC)=7.158;治疗后t_(CRP)=7.263、t_(WBC)=6.995,均P<0.05),普通型HFMD患儿治疗后CRP水平较重症型降低明显,比较治疗前后CRP差值差异有统计学意义(t_(CRP)=6.882,P=0.041),普通型与重症型HFMD患儿治疗后WBC计数均较治疗前降低,但治疗前后差值比较差异无统计学意义(t_(WBC)=2.354,P=0.135);④治疗前CRP水平与HFMD患儿康复时间呈正相关性(r=0.614,P<0.05),WBC与HFMD患儿康复时间相关性检验无统计学意义(P>0.05)。结论手足口病患儿CRP检测阳性率高于WBC计数,病情越重其水平越高,康复时间越长,在评估手足口病患儿病情及预后方面具有显著优势。
Objective To discuss the effect of C-reactive protein （CRP） on assessing the disease and prognosis of children with hand, foot and mouth disease （HFMD）. Methods Totally 60 cases of HFMD were selected from Shaoxing Shangyu People＇ s Hospital, and they were divided into common cases （n = 64） and severe cases （ n = 36） according to the severity of disease. CRP level and WBC count were detected. Results The positive rate of CRP and WBC was 95% （95/100） and 82% （82/100）, respectively, and the difference was significant （χ^2 =7. 258, P 〈 0.05 ）. Before treatment the CRP positive rate of severe HFMD cases was 100% （36/36）, which was significantly higher than that of common cases 92.19% （59/64） （χ^2 = 6. 175, P 〈 0.05）. There was no significant difference in WBC positive rate between severe cases and common cases （χ^2 = 1. 224, P 〉 0.05）. Both before and after treatment the CRP level and WBC count of severe cases were higher than those of common cases with significant difference （ before treatment ： tCRP = 8. 452, tWBC= 7. 158 ; after treatment tenr, = 7. 263 ,tWBC = 6. 995, all P 〈 0.05）. After treatment the decrease of CRP level in common cases was more significant than that in severe cases （tcRv = 6. 882, P = 0. 041 ）. Both common cases and severe cases had lower WBC count after treatment, and the changes were not statistically significant （ tWBC = 2. 354, P = 0. 135 ）. The CRP level before treatment was positively correlated with the rehabilitation time （ r = 0. 614 ,P 〈 0.05 ）, but WBC count was not correlated with it （ P 〉 0.05 ）. Conclusion HFMD children have higher CRP testing positive rate than WBC count. The more severe the disease, the higher the level and the longer the rehabilitation time. CRP has priority in assessing disease condition and prognosis of children with HFMD.
出处
《中国妇幼健康研究》
2015年第1期60-62,共3页
Chinese Journal of Woman and Child Health Research
关键词
手足口病
C-反应蛋白
白细胞计数
病情
预后
hand, foot and mouth disease （HFMD）
C-reactive protein （CRP）
white blood cell count
disease
prognosis
