摘要
目的了解大连市先天性甲状腺功能减低症（CH）患儿检出情况及早期干预对其体格智能发育的影响。方法选取2007年10月至2012年9月筛查并确诊的50例CH患儿为实验组，按照1：1配对选择正常婴儿为对照组，均给予早期综合促进指导，定期监测体重、身长、智力、运动发展指数。结果5年间大连市CH（不包括高TSH血症）发病率0．22‰（1：4544），确诊及治疗年龄为8—53天，经过早期综合促进干预，CH患儿周岁体重均值（10．11±0．93）kg、身长均值（75．63±2．21）cm及智力发育指数（102．90±8．10）、运动发育指数（101．60±8．70）与正常同龄儿差异均无统计学意义（t值分别为1．02、1．03、1．23和1．34，均P〉0．05）。结论早期治疗加以实施早期综合促进有助于CH患儿的体格和智能发育。
Objective To learn the detection of congenital hypothyroidism （CH） among infants in Dalian City and the influence of early intervention on infants＇ physical and intellectual development. Methods A total of 50 infants screened and diagnosed with CH during the period of October 2007 to September 2012 were included in experimental group, and healthy controls were selected with the ratio of 1：1. Early comprehensive guidance was given to two groups, and weight, length, mental and psychomotor development indexes of two groups were monitored regularly. Results The incidence of CH （ not including high TSH hyperlipidemia） in Dalian during 5 years was 0.22 %o （ 1 ： 4 544）, and the age of diagnosis and treatment was 8 to 53 days. After the early comprehensive intervention, the mean weight （ 10.11± 0.93kg）, mean length （75.63 ± 2.21cm）, mental development index （ 102.90 ± 8.10） and psychomotor development index （ 101.60 ± 8.70） of the CH infants were not significantly different from those of the healthy infants at the age of one year （t value was 1.02, 1.03, 1.23 and 1.34 ; respectively, all P 〉 0.05）. Conclusion Early treatment combined with early comprehensive intervention can promote the physical and mental development of infants with CH.
出处
《中国妇幼健康研究》
2015年第1期128-129,142,共3页
Chinese Journal of Woman and Child Health Research
关键词
先天性甲状腺功能减低症
早期治疗
定期监测
体格发育
智能发育
congenital hypothyroidism （CH）
early treatment
regular monitoring
physical development
mental development
