摘要
目的探讨采用高压氧规范方案治疗新生儿缺氧缺血性脑病(HIE)的临床效果。方法选择平煤神马医疗集团总医院2012年2月至2014年2月收治的HIE 60例作为研究对象,随机分为常规治疗组(对照组,n=30)与在常规治疗基础上加用高压氧规范方案治疗组(试验组,n=30),以神经行为评分(NBNA)、意识障碍消失时间、肌张力恢复时间、平均住院时间和有效率进行比较。结果治疗10d后,试验组NBNA得分明显高于治疗5d后,且均高于对照组治疗10d后的NBNA得分(t值分别为9.30、8.91,均P<0.05);试验组患儿肌张力恢复时间、意识障碍消失时间、平均住院时间均少于对照组(t值分别为4.23、8.02、6.27,均P<0.05);两组治疗有效率分别为93.3%和70%,差异具有统计学意义(x^2=7.38,P<0.05)。结论新生儿颅内缺氧缺血应用高压氧规范方案治疗,可缩短病程,提高临床治疗效果,值得推广。
Objective To investigate the clinical efficacy of hyperbaric oxygen specification program therapy for neonatal hypoxic ischemic eneephalopathy （HIE）. Methods From February 2012 to February 2014, 60 neonates with HIE were selected in General Hospital of Pingmei Shenma Medical Group and randomly divided into conventional treatment group （ control group, n = 30 ） and hyperbaric oxygen plus conventional treatment group （ test group, n = 30 ）. The effects of two groups were compared in terms of neonatal behavioral neurological assessment （NBNA） , consciousness recovery time, muscular tension recovery time, duration of hospital stay and effective rate. Results After 10-day treatment, NBNA of the test group was significantly higher than that after 5-day treatment and that of the control group after 10-day treatment （t value was 9.30 and 8.91, respectively, both P 〈 0.05）. Muscular tension recovery time, consciousness recovery time and duration of hospital stay of the test group were less than the control group （t value was 4.23, 8.02, and 6.27, respectively, all P 〈0.05）. The effective rate was 93.3% and 70% in the test group and the control group, respectively, and the difference was statistically significant （χ^2 = 7.38, P 〈 0. 05 ）. Conclusion Application of hyperbaric oxygen specification program therapy for neonatal HIE can shorten the course and improve clinical efficacy. It is worthy of spread in clinics.
出处
《中国妇幼健康研究》
2015年第1期138-139,144,共3页
Chinese Journal of Woman and Child Health Research
关键词
新生儿
缺氧缺血性脑病
高压氧
疗效
neonate
hypoxic ischemie eneephalopathy （HIE）
hyperbaric oxygen
curative efficacy
