摘要
在中医药传统使用中,泽泻是一种常见的中药。随着临床应用中毒性报道日益增加,而其肾毒性逐渐得到关注。该文系统回顾了化学物质基础的相关研究,包括其化学成分和可能的毒性成分;以网络毒理学研究为基础,叙述了泽泻毒性作用。基于泽泻肾毒性研究的争议,剖析了可能存在的原因,认为泽泻肾毒性可能与药材的毒性物质基础组分导致的毒理网络调控差异、采用的样品炮制工艺存在差别、代谢功能强弱导致的成分蓄积、实验的剂量与时间长短及其复方配伍等因素有关。该文为提高泽泻的质量控制水平和科学合理使用泽泻提供了一定的参考和思路。
Alisma orientalis is a traditional herb medicine commonly used in clinical. With the increasing report of its toxicity in clinical, the renal toxicity of Alisma orientalis has got gradually attention. This paper systematically reviews the research on thechemical material basis of Alisma orientalis including its chemical composition and toxicity of ingredients ; and also declares its toxic ingredients and targets according to Network toxicology. Based on the controversy on renal toxicity of Alisma orientalis, we analyzed the possible reasons that may be associated with renal toxicity. It might be associated with the differences of the material basis composition and regu- latory toxicology network, differences in employed processing technology, the metabolic function leading to accumulation of compounds, dosage and duration of the experiment and compatibility. The review provides possible reference and ideas for the quality control and ra- tional use of Alisma orientalis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2015年第5期840-846,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81202906
81473394)
关键词
泽泻
毒性成分
肾损伤
Alisma orientalis
toxic ingredients
kidney injury
