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视黄醇结合蛋白4检测在营养性疾病及肝肾损害检测中的临床应用 被引量:6

Assessment of Retinol Binding Protein 4 in Nutritional Diseases and Liver or Kidney Diseases
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摘要 视黄醇结合蛋白(retinol binding protein,RBP)是一种分泌型视黄醇结合蛋白,主要合成于肝脏,广泛分布于人体血液、尿液等体液中的视黄醇(VitA)运载蛋白,在协助 VitA发挥生理功能中起到关键作用。最新研究表明:RBP4是一种新的脂肪细胞因子,参与胰岛素抵抗和2型糖尿病的发生,与糖尿病肾病、营养性疾病等的发展存在着一定的相关性。这一发现使得 RBP4更加受到人们的重视。该文就 RBP4的生理功能,在肝肾疾病、糖尿病等各类疾病方面的应用以及新型临床检测方法作一综述。 Retinol binding protein 4 (RBP4)was a class of secreting protein,mainly synthesized by the liver,widely distributed in the human body blood,urine and other body fluids.It plays an important role in assisting the physiological function of vitamin A.Recent research shows that RBP4 was a new kind of adipocytokine,participated in insulin resistance and occurrence of type 2 diabetes,and had a closed relationship with diabetic nephropathy,nutritional disease.This article describes the function of RBP4,review the relationship between RBP4 and nutritional or other type of diseases,and new clinical detection method with RBP4.
出处 《现代检验医学杂志》 CAS 2015年第1期1-3,7,共4页 Journal of Modern Laboratory Medicine
基金 本课题系国家自然科学基金面上项目(31270963) 上海市科委重点连续资助项目(10JC1408500) 上海市科委生物医药领域科技支撑项目2014年度“科技创新行动计划”项目(14431903700) 上海交通大学医学院附属瑞金医院优青项目(8003).
关键词 视黄醇结合蛋白4 营养性疾病 肝肾损害 retinol binding protein 4 nutritional diseases liver and kidney damage
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