摘要
目的：探讨年龄因素对癫痫患儿奥卡西平代谢产物血药浓度的影响。方法将200例患儿按年龄分为四个研究组，A组：＜3岁婴幼儿，B组：3-6岁学龄前期儿童，C组：7-13岁学龄期儿童，D组：14-18岁青少年，每个研究组50例患儿；采用高效液相色谱法对奥卡西平活性代谢产物（MHD）血清稳态血药浓度测定，分析年龄因素与其血药浓度关系。结果奥卡西平活性代谢产物（MHD）稳态血药浓度随着年龄增长有上升趋势，但差异无统计学意义（P＞0.05）。结论奥卡西平血清 MHD浓度在癫痫患儿中个体差异较大，应在服用过程中动态监测血药浓度，及时调整用药剂量，促进给药方案个体化实施。
Objective To investigate effects of blood serum concentration of MHD in children with epilepsy of different ages. Methods Two hundred children with epile psy were divided into four groups according to age,group A：〈3 years old infants;group B：3-6 years old preschoolers;group C：7-13 years old school-age chidren.Group D：14-18 years old adolescents,each group had 50 chidren.The serum concentration of active metabolite was detected by high-perform ance liquid chromatography （HPLC）method.Results The serum concentration of MHD increase with age,but there were no statistical significance （P〉0.05）.Conclusion The indiv idual variation in blood serum concentrations of MHD in children with epilepsy adminisered with oxcarbazepine is high,therefore monitoring the blood serum concentration is helpful to adj ust the dose of medication and to promote the implementation of the individualized dosing regimens.
出处
《现代检验医学杂志》
CAS
2015年第1期143-144,148,共3页
Journal of Modern Laboratory Medicine
关键词
奥卡西平
代谢产物
血药浓度
癫痫
年龄
oxcarbazepine
metabolite
serum concentration
epilepsy
age
