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血液透析患者动脉粥样硬化危险因素及相关性研究 被引量:2

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摘要 目的研究维持性血液透析(MHD)患者颈动脉粥样硬化(AS)的危险因素及其相关性。方法检查158例MHD患者血清白蛋白(ALB)、血红蛋白(Hb)、血尿素氮(BUN)、血肌酐(Cr)、血脂、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及成纤维细胞生长因子23(FGF23)浓度等,超声技术测定颈动脉中层厚度(IMT)及粥样硬化斑块,分析MHD患者AS的危险性及相关性。结果 AS组年龄及hs-CRP、FGF23、Hcy、TNF-α水平与非AS组比较差异有统计学意义(P<0.05或P<0.01),其他检测指标比较差异无统计学意义。非条件Logistic回归分析结果显示,hs-CRP、FGF23、Hcy和TNF-α均与AS密切相关(P<0.05或P<0.01)。结论 hs-CRP、TNF-α、血清Hcy及FGF23的升高可作为AS的危险预测指标,并与其独立相关。同时防治微炎症状态及动态监控FGF23可缓减AS进展,减少心血管并发症,提高患者生存率。
作者 鲁勤波
机构地区 湖北省鄂钢医院
出处 《现代中西医结合杂志》 CAS 2015年第10期1081-1082,1089,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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