摘要
特发性肺纤维化(IPF)是以进行性呼吸困难、肺间质浸润和肺功能受限为主要特征的一种特殊疾病。IPF是特发性间质性肺炎最常见、最严重的类型。IPF发病机制的观念已经从慢性炎症演变为组织损伤后的异常修复过程。新的观点认为IPF是包括炎性反应和组织损伤修复在内的多种原因及途径共同作用的结果。该文旨在回顾历史,对IPF发病机制研究的变迁和目前的新进展进行梳理和综述。
Idiopathic pulmonary fibrosis（ IPF） is a special disease characterized by progressive dyspnea,interstitial infiltration in lung parenchyma,and restriction on pulmonary function. IPF is the most common and severe type of the idiopathic interstitial pneumonias. The concept of the pathogenesis of IPF has evolved from chronic inflammation to aberrant wound healing. And there are some new ideas considering that the pathogenesis of IPF is the result of multi-cause and multi-way process including inflammation and repair after injury.Here is to make a review of the history with the aim to trace the evolution in the hypothesis of pathogenesis of IPF.
出处
《医学综述》
2015年第2期207-210,共4页
Medical Recapitulate
基金
北京市卫生系统高层次卫生技术人才培养计划资助(2011-3-081)
关键词
特发性肺纤维化
慢性炎症
肺泡上皮细胞
机制
Idiopathic pulmonary fibrosis
Chronic inflammation
Alveolar epithelial cells
Mechanisms
