期刊文献+

甲状腺癌组织中Caspase-9、Livin表达的临床意义 被引量:3

Clinical significance of expression of Caspase-9,Livin in thyroid cancer tissue
下载PDF
导出
摘要 目的探讨甲状腺癌组织中半胱氨酸天冬氨酸蛋白酶(caspase)-9和凋亡抑制蛋白因子(Livin)表达的临床意义。方法检测65例甲状腺癌组织和40例正常甲状腺组织中Caspase-9、Livin表达情况,分别比较Caspase-9、Livin在两种不同组织中表达的阳性率,分析Livin、Caspase-9在甲状腺癌组织中表达情况与临床病理因素的关系,应用Spearman等级相关检验分析Livin、Caspase-9在甲状腺癌组织表达的相关因素。结果 Livin、Caspase-9阳性染色主要位于细胞质内,表现为小片状分布的棕黄色或黄褐色颗粒;甲状腺癌组织中Caspase-9阳性表达率低于正常甲状腺组织(χ2=38.149,P=0.000),Livin阳性表达率高于正常甲状腺组织(χ2=43.161,P=0.000);Livin、Caspase-9在甲状腺癌组织中的表达与患者的年龄、性别及肿瘤的大小、病理类型无关(P>0.05),而与肿瘤的临床分期、淋巴转移和包膜浸润有关(P<0.05);Livin、Caspase-9在甲状腺癌组织中的表达呈负相关(r=-0.346,P<0.05)。结论甲状腺癌组织中Caspase-9表达下调,Livin表达升高,二者的异常表达参与甲状腺癌的发生和发展过程,Livin、Caspase-9联合检测可作为判断甲状腺癌患者预后的重要参考指标。 Objective To investigate the clinical significance of expression of cysteine aspartic acid protease(caspase)-9,Livin in thy-roid cancer tissue. Methods The expression of Caspase-9,Livin of thyroid cancer tissue in 65 patients and normal thyroid tissue in 40 patients were detected. The positive rate of expression of Caspase-9,Livin were compared in two different kind of tissues. The relationship between the expression of Livin,Caspase-9 and clinical pathological factors were analyzed withχ2 test. The relationship of expression of Livin,Caspase-9 in thyroid carcinoma tissue were analyzed with Spearman rank correlation test. Results Livin,Caspase-9 positive staining was mainly located in cytoplasm,and it was showed brown yellow patchy distribution or yellow brown granular. The positive expression rate of Caspase-9 was lower than that of normal thyroid tissue in thyroid cancer tissue(χ2 =38. 149,P =0. 000),the positive expression rate of Livin was higher than that of nor-mal thyroid tissue(χ2 =43. 161,P =0. 000). The expression of Livin,Caspase-9 in thyroid cancer tissue had nothing to do with the age,gen-der,tumor size and histologic types of patients( P ﹥0. 05),but it related to the tumor staging,lymph node metastasis and diolame invasion( P﹤0. 05). The expression of Livin,Caspase-9 in thyroid cancer tissues presented negative correlation( r = -0. 346,P ﹤0. 05). Conclusion Expression of Caspase-9 down-regulated in thyroid cancer tissue,while the expression of Livin increased,the abnormal expression participa-ted in the occurrence and development of thyroid cancer. The combined detection of Livin,Caspase-9 can be used as an important reference in-dex in judging the prognosis in patients with thyroid carcinoma.
出处 《临床和实验医学杂志》 2015年第5期371-373,共3页 Journal of Clinical and Experimental Medicine
关键词 甲状腺癌 半胱氨酸天冬氨酸蛋白酶-9 LIVIN 细胞凋亡 Livin Thyroid cacer Livin Apoptosis binding protein
  • 相关文献

参考文献6

二级参考文献50

  • 1姚榛祥.甲状腺癌的分子生物学研究进展[J].临床外科杂志,2006,14(3):140-141. 被引量:12
  • 2李树玲.我国甲状腺癌外科现状与展望[J].临床外科杂志,2006,14(3):129-130. 被引量:46
  • 3Frates MC, Benson CB, Charhoneaff JW, et M. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement [J]. Radiology, 2005,237 (3):794-800.
  • 4Haymarl MR, Repplingcr DJ, Leverson GE, et al. Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage [J]. J Clin Endocrinol Metab ,2008,93(3): 809-814.
  • 5Layfield LJ, Cibas ES, Gharib H, et al. Thyroid aspiration cytology: current status [J]. CA Cancer J Clin ,2009,59(2):99-110.
  • 6Tanaka T, Ishiguro H, Kuwabara Y, et al. Vascular endothelial growth factor C (VEGF-C) in esophageal cancer correlates with lymph node metastasis and poor patient prognosis[J]. J Exp Clin Cancer Res, 2010, 29(1):83.
  • 7Troviseo V,Soares P,Preto A, et al. Moleettlar genetics of papil- lary thyroid carcinoma: great expectation[J]. Arq Bras Endocri- nol Metabol, 2007,51 (5) : 643-653.
  • 8Strappazzon F, Torch S, Chatellard-Causse C, et al. Alix is in- volved in Caspase-9 activation during calcium-induced apoptosis [J].Biochem Biophys Res Commun, 2010,397 (1) : 64-69.
  • 9Ekonomopoulou MT,Babas E,Mioglou -Kalouptsi E. Changes in activities of easpase-8 and Caspase-9 in human eervieal malignan- ey[J]. Int J Gyneeol Cancer,2011,21(3) :435.
  • 10Bratton SB,Salvesen CS. Regulation of the Apaf-l-Caspase-9 ap- optosome[J]. J Cell Sci, 2010,123 (Pt 19) : 3209-3214.

共引文献58

同被引文献26

引证文献3

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部