摘要
目的观察依那普利联合氯沙坦治疗老年糖尿病肾病(DN)合并高血压的临床疗效。方法 70例DN患者随机分为观察组38例及对照组32例,对照组常规治疗的基础上给予氯沙坦治疗,观察组在对照组基础上加用依那普利,两组均连续治疗12周。结果两组均有较佳的降压疗效,组间无显著差异(P>0.05);治疗后两组血肌酐(Scr)、尿素氮(BUN)及24小时尿微量白蛋白排泄率(UAER)均较治疗前显著下降(P<0.01),且观察组显著低于对照组(P<0.05或P<0.01)。结论依那普利联合氯沙坦治疗老年糖尿病肾病合并高血压疗效确切,其对肾功能的改善效果较单用氯沙坦更优,且不增加不良反应。
Objectives To observe the efficacy of enalapril combined with losartan in the treatment of senile diabetic nephropa -thy （ DN） complicated by hypertension .Methods Seventy patients with DN were randomly divided into observation group （ n=38） and control group （n=32）.Control group was treated with losartan based on routine treatment for 12 weeks, whereas observa-tion group was added enalapril based on the treatment of control group for 12 weeks.Results Better effects of decreasing blood pressure were obtained in both groups , but there was no statistical significance （ P〉0.05 ） .The levels of serum creatinine （ Scr ） and urea nitrogen （BUN） as well as urinary albumin excretion rates （UAER） for 24 hours in both groups went down significantly compared with treatment before （P〈0.01）, and those in observation group were markedly lower than in control group （P〈0.05 or P〈0.01）.Conclusions Without increasing adverse reactions , efficacy of enalapril combined with losartan for senile DN compli-cated by hypertension is precise and superior to application of losartan alone in improvement of renal function .
出处
《中国老年保健医学》
2015年第1期61-62,共2页
Chinese Journal of Geriatric Care
基金
中国高校医学期刊临床专项资金(11321679)
关键词
依那普利
氯沙坦
糖尿病肾病
高血压
enalapril
losartan
diabetic nephropathy
hypertension
