摘要
目的制备替比培南酯缓释片并对其体外释药特性进行研究。方法选用羟丙甲纤维素K4M、羟丙甲纤维素K15M为缓释骨架材料制备替比培南酯缓释片。采用正交设计法,以药物体外累积释放百分率为考察指标优化处方。结果制备的缓释片具有明显的缓释特征,体外释放符合一级释药动力学方程,释药机制为非Fick扩散。结论制备的替比培南酯缓释片具有较理想的体外缓释效果。
Objective To prepare Tebipenem Pivoxil Sustained- release Tablets and investigate the drug release mechanism in vitro. Methods HPMC K4 M and HPMC K15 M were used to prepare Tebipenem Pivoxil Sustained- release Tablets as matrix materials. Using the accumulative dissolution in vitro at different sampling time as the evaluation index,the formulation was optimized by the orthogonal design test. Results The optimal formulation had a remarkable sustained- release property,the drug release profile in vitro followed first order kinetics,of which the mechanism was non- Fick diffusion. Conclusion The prepared tablets exhibited more ideal sustained- release characteristics in vitro.
出处
《药学研究》
CAS
2015年第3期166-167,171,共3页
Journal of Pharmaceutical Research
关键词
替比培南酯
缓释片
正交设计
释放度
Tebipenem pivoxil
Sustained-release tablets
Orthogonal design
Dissolution
